Document Detail

Comparison of short- and long-term outcomes between Cypher and TAXUS drug-eluting stents for in-stent restenosis.
MedLine Citation:
PMID:  17441309     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the short- and long-term clinical outcomes between sirolimus-eluting stent (Cypher stent) and paclitaxel-eluting stent (TAXUS stent) in patients with in-stent restenosis (ISR) lesions of the coronary arteries. METHODS: From December 2002 to March 2005, 253 patients with ISR lesions of the coronary arteries were selected and divided into two groups. Cypher group (152 cases) was treated with Cypher or Cypher Select stents, and TAXUS group (101 cases) with TAXUS stents. A total of 262 ISR lesions in these patients were treated with 308 drug-eluting stents (DESs), including 176 Cypher or Cypher Select stents and 132 TAXUS stents. All patients were followed up for 10 months. Procedure success rates of DES implantation in both groups were observed. Major adverse cardiac events (MACE) rates in hospital and at 10 months follow-up, as well as in-DES restenosis observed using coronary angiography at follow-up were compared between two groups. RESULTS: Success rate of DES implantation was 100% in both groups. No significant difference in MACE rate during hospitalization was found between the two groups. However, at 10 months follow-up, MACE rate was higher in TAXUS group than in Cypher group (16.00% vs. 6.67% , P = 0.031). As for coronary angiography at 10 months follow-up, we observed an increasing tendency of in-DES restenosis rate in TAXUS group compared with Cypher group (29.41% vs. 14.04%, P = 0.075). CONCLUSIONS: Cypher and TAXUS DESs both have good short- and long-term outcomes in treating ISR. Cypher DES proved better long-term clinical outcome than TAXUS DES.
Ji-Lin Chen; Yue-Jin Yang; Shu-Bin Qiao; Min Yao; Xue-Wen Qin; Bo Xu; Hai-Bo Liu; Yong-Jian Wu; Jin-Qing Yuan; Jue Chen; Shi-Jie You; Jun Dai; Jian-Jun Li; Run-Lin Gao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences     Volume:  22     ISSN:  1001-9294     ISO Abbreviation:  Chin. Med. Sci. J.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-04-19     Completed Date:  2009-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112559     Medline TA:  Chin Med Sci J     Country:  China    
Other Details:
Languages:  eng     Pagination:  5-8     Citation Subset:  IM    
Center for Diagnosis & Treatment of Coronary Heart Disease, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037.
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MeSH Terms
Angina Pectoris / surgery
Coronary Disease / mortality,  surgery*
Equipment Design
Middle Aged
Myocardial Infarction / epidemiology
Stents* / adverse effects
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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