Document Detail


Comparison of short and long ovulation induction protocols used in ART applications according to the ovarian response and outcome of pregnancy.
MedLine Citation:
PMID:  11998967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This retrospective study was designed to determine whether there is any difference between short and long protocol ovulation induction with Gonadotropin Releasing Hormone agonist (GnRHa) and gonadotropins used in Assisted Reproductive Technology (ART) applications according to the number of retrieved oocytes, oocyte maturity, fertilization rates, embryo quality and the outcome of pregnancies. 240 cycles consisting of in vitro fertilization (IVF) cycles without andrologic factor and intracytoplasmic sperm injection (ICSI) cycles were evaluated. 112 cycles which were induced by short protocol GnRHa and Follicle Stimulating Hormone (FSH) + Human Menopausal Gonadotropin (HMG) combinations and 128 cycles which were induced by long protocol GnRHa and FSH + HMG combinations were compared according to the number of retrieved oocytes, cancellation rate of cycles, oocyte maturity, fertilization rates, embryo quality and pregnancy rates. The cancellation rate for short protocol cycles were found to be significantly higher than those with long protocol. The number of retrieved oocytes, mature oocytes and fertilized oocytes were also found significantly lower. The quality of embryos did not show any significant difference between these groups. The clinical pregnancy rates were evidently found to be high in the long protocol cycles. As a conclusion we have found that while the number of retrieved oocytes, mature oocytes, fertilized oocytes and clinical pregnancy rates were increasing, the cancellation rate of cycles were decreasing significantly in ART cycles induced by long protocol.
Authors:
E Tavmergen; E N Tavmergen Göker; F Sendag; H Sendag; R Levi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  266     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-05-09     Completed Date:  2002-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  5-11     Citation Subset:  IM    
Affiliation:
Department of Gynecology and Obstetrics, Ege University, Izmir, Turkey. tavmerge@med.ege.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Cell Count
Embryo Transfer
Estradiol / blood
Female
Fertilization in Vitro
Follicle Stimulating Hormone / administration & dosage,  blood
Gonadotropin-Releasing Hormone / agonists
Humans
Menotropins / administration & dosage
Oocytes
Ovary / physiology*
Ovulation Induction / methods*
Pregnancy
Pregnancy Outcome*
Reproductive Techniques, Assisted*
Retrospective Studies
Sperm Injections, Intracytoplasmic
Tissue and Organ Harvesting
Chemical
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 61489-71-2/Menotropins; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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