| Comparison of seven immunoassays for the quantification of CA 125 antigen in serum. | |
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MedLine Citation:
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PMID: 9665418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seven CA 125 immunoassays were compared for their clinical performance. CA 125 concentrations were determined in 289 serum samples obtained from women with benign pelvic tumors (samples from 98 patients) and patients with various cancers (samples from 111 patients). In the range of 0-1000 kilounits/L, all assays tested were linearly correlated, with correlation coefficients ranging from 0.89 to 0.99. In relation to the original Centocor CA 125 assay, there was an overall tendency to measure higher absolute values in the lower CA 125 value range. This was not seen in relation to the Centocor CA 125 II assay. ROC curves (benign vs pretreatment ovarian cancer patients) were nearly identical for all assays, and the areas under the ROC curves were not markedly different. We conclude that the CA 125 assays tested are strongly related to each other and are clinically reliable for the quantification of serum CA 125 and that none of the assays offers higher diagnostic accuracy or better discrimination between patient groups, especially not in the lower ranges. |
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Authors:
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E M Davelaar; G J van Kamp; R A Verstraeten; P Kenemans |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical chemistry Volume: 44 ISSN: 0009-9147 ISO Abbreviation: Clin. Chem. Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-07-23 Completed Date: 1998-07-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421549 Medline TA: Clin Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1417-22 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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blood Antibodies, Monoclonal / immunology CA-125 Antigen / blood*, immunology Colonic Neoplasms / blood Female Humans Immunoassay / methods Leiomyoma / blood Linear Models Ovarian Neoplasms / blood* ROC Curve Reproducibility of Results Uterine Neoplasms / blood |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/CA-125 Antigen |
| Comments/Corrections | |
Comment In:
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Clin Chem. 1998 Jul;44(7):1379-80
[PMID:
9665412
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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