Document Detail

Comparison of serum myoglobin and creatine kinase MB isoenzyme in early diagnosis of acute myocardial infarction.
MedLine Citation:
PMID:  7225253     Owner:  NLM     Status:  MEDLINE    
We compared the clinical usefulness of serum myoglobin and creatine kinase MB (CK MB) isoenzyme determinations in the early diagnosis of acute myocardial infarction in 109 consecutive patients admitted to a coronary care unit. Of these, 37 patients were diagnosed as having definite infarction, three possible infarction, and 69 no infarction, using World Heath Organisation criteria. Blood samples were taken on admission and two to four hours later, Both CK MB and myoglobin were raised in the initial serum samples in 24 of the 37 patients with definite infarction. In an additional seven patients both CK MB and myoglobin were negative in the first specimen though both were detected in the second sample. In five patients CK MB preceded the appearance of myoglobin while in the remaining patient myoglobin appeared before CK MB. We conclude that the detection of serum myoglobin does not offer any clinical advantage over CK MG as an early indicator of myocardial infarction.
A P Freeman; K R Fatches; I W Carter; M J Cloonan; D E Wilcken
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  45     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  389-92     Citation Subset:  AIM; IM    
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MeSH Terms
Acute Disease
Clinical Enzyme Tests
Creatine Kinase / blood*
Myocardial Infarction / diagnosis*
Myoglobin / blood*
Time Factors
Reg. No./Substance:
0/Isoenzymes; 0/Myoglobin; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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