Document Detail

Comparison of serum free thyroxine measurements by chemiluminescence and equilibrium dialysis.
MedLine Citation:
PMID:  2801248     Owner:  NLM     Status:  MEDLINE    
A study of 239 patients compared free thyroxine (FT4) measurements made by equilibrium dialysis (ED) with measurements made using the Magic Lite FT4 chemiluminescence (CI) immunoassay (Ciba Corning Immunodiagnostics). Patient groups: 41 normals; 27 hyperthyroid; 29 hypothyroid; 37 sick euthyroid; 10 chronic renal failure (CRF) and 25 pregnant patients; 13 oestrogen; 10 heparin; 12 salicylate; and 9 dilantin-treated patients; 3 lipaemic; 5 haemolysed; 6 hyperbilirubinaemic patients; 6 low thyroid binding protein (TBP) and 6 high TBP level patients. The two assays gave comparable results in most groups. Both assays tended to give elevated values in heparinized patients but FT4-ED results were more obviously affected. Pregnant patients and women on oral oestrogen had higher mean values with FT4-ED. In both assays the sick euthyroid and CRF patients had mean FT4 values similar to healthy euthyroid patients; the range of values in sick euthyroid and CRF patients was similar in both assays but wider than in healthy euthyroid patients. A supplemental study of 81 unselected acutely ill patients using FT4-Cl alone confirmed the wider range of values to be anticipated in sick euthyroid patients.
S T Bigos; J MacLean; B Butler
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of bioluminescence and chemiluminescence     Volume:  4     ISSN:  0884-3996     ISO Abbreviation:  J. Biolumin. Chemilumin.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-11-06     Completed Date:  1989-11-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8612490     Medline TA:  J Biolumin Chemilumin     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  627-34     Citation Subset:  IM    
Division of Endocrinology, Maine Medical Center, Portland, Maine 04102.
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MeSH Terms
Evaluation Studies as Topic
Immunoassay / methods*
Luminescent Measurements*
Middle Aged
Reference Values
Thyroid Diseases / blood
Thyroxine / blood*
Reg. No./Substance:
7488-70-2/Thyroxine; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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