Document Detail


Comparison of serial debulking and cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in pseudomyxoma peritonei of appendiceal origin.
MedLine Citation:
PMID:  24965858     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: Patients with pseudomyxoma peritonei (PMP) benefit from cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Reports on this modality usually have included only patients with successful HIPEC treatment, which can potentially cause biased results. We report the survival of a PMP population treated by CRS and HIPEC, including patients who were not eligible for HIPEC.
METHODS: The outcome of the whole population of 87 patients with PMP treated by CRS and HIPEC in Helsinki University Central Hospital between 2008 and 2011 was evaluated. The results of treatment were compared with 33 patients treated by serial debulking in our unit between 1984 and 2008.
RESULTS: Of the 87 patients in the HIPEC-era group, 56 received HIPEC, 12 were treated non-radically in an attempt at HIPEC, 9 were debulked and 10 were referred back or transferred to palliative care without surgery. The 5-year overall survival for the debulking-era group and the HIPEC-era group were 67 and 69 %, respectively. The number of patients with no evidence of disease was higher in the HIPEC-era group (47/87) than that in the debulking-era group (8/33) at the end of the follow-up. Overall survival for patients who underwent successful CRS and HIPEC at 2 and 5 years was 95 and 93 %, respectively.
CONCLUSIONS: The improved survival from using the CRS and HIPEC was not apparent after 5-year follow-up, when the whole patient population was included in the analysis. Even so, patients successfully treated by CRS and HIPEC manage well.
Authors:
Petrus Järvinen; Ari Ristimäki; Jonas Kantonen; Merja Aronen; Riikka Huuhtanen; Heikki Järvinen; Anna Lepistö
Related Documents :
21739158 - Feasibility and effectiveness of inhaled carboplatin in nsclc patients.
8845608 - Skip metastasis and hidden n2 disease in lung cancer: how successful is mediastinal dis...
3626598 - Replacement of the superior vena cava with polytetrafluoroethylene grafts combined with...
21912118 - Randomized phase ii study of two schedules of carboplatin and gemcitabine for stage iii...
21051988 - Serum hcg level and rising world health organization score at second-line chemotherapy ...
9586878 - Tumor clearance of technetium 99m-sestamibi as a predictor of response to neoadjuvant c...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-26
Journal Detail:
Title:  International journal of colorectal disease     Volume:  -     ISSN:  1432-1262     ISO Abbreviation:  Int J Colorectal Dis     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607899     Medline TA:  Int J Colorectal Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Anorectal complications and function in patients suffering from inflammatory bowel disease: a series...
Next Document:  Short-term outcome of laparoscopic versus robotic ventral mesh rectopexy for full-thickness rectal p...