Document Detail

Comparison of the sensory threshold in healthy human volunteers with the sensory nerve response of the rat in vitro hindlimb skin and saphenous nerve preparation on cutaneous electrical stimulation.
MedLine Citation:
PMID:  7594979     Owner:  NLM     Status:  MEDLINE    
We report a comparative study of stimulation thresholds of cutaneous fibres of the rat in vitro skin and saphenous nerve preparation with psychophysical measurements of sensibility to cutaneous electrical stimulation in human volunteers. The same clinical diagnostic stimulator and modified skin electrodes were used in both animal and human experiments. Axons were recruited by increasing the stimulus strength, and correlation was made between the stimulus intensity required for unit activation and their conduction velocities. The findings suggest that an initial "tingling" sensation is due to recruitment of A beta fibres and that later sharp "pricking" occurs with recruitment of A delta fibres.
R M McAllister; L A Urban; A Dray; P J Smith
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hand surgery (Edinburgh, Scotland)     Volume:  20     ISSN:  0266-7681     ISO Abbreviation:  J Hand Surg Br     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-12-05     Completed Date:  1995-12-05     Revised Date:  2009-06-08    
Medline Journal Info:
Nlm Unique ID:  8403839     Medline TA:  J Hand Surg Br     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  437-43     Citation Subset:  IM    
Sandoz Institute for Medical Research, Department of Pharmacology, London, UK.
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MeSH Terms
Analysis of Variance
Electric Stimulation
Fingers / innervation
Hindlimb / innervation*
Nerve Fibers / physiology
Neural Conduction
Peripheral Nerves / physiology*
Rats, Sprague-Dawley
Recruitment, Neurophysiological
Sensation / physiology
Sensory Thresholds*
Skin / innervation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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