Document Detail


Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide.
MedLine Citation:
PMID:  3743707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intracerebroventricular kainic acid produces in rats brain lesions similar to Ammon's horn sclerosis in humans. To test the hypothesis that these lesions result indirectly from prolonged seizure activity and not from a direct action of kainic acid on the neurons that are destroyed, the effects of intracerebroventricular kainic acid and bicuculline methiodide were compared. Although bicuculline methiodide seizures differed dramatically from kainic acid seizures, both electrographically and behaviorally, the resulting brain lesions were similar for a given total limbic seizure duration. These results, in combination with other data, support the view that lesions made by intracerebroventricular administration of convulsants are indeed caused by prolonged limbic seizures. The total duration of seizure activity appears to be one important variable.
Authors:
M Gruenthal; D R Armstrong; B Ault; J V Nadler
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental neurology     Volume:  93     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-10-07     Completed Date:  1986-10-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  621-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bicuculline / administration & dosage,  analogs & derivatives*
Brain Diseases / chemically induced*,  physiopathology
Hippocampus / physiopathology
Injections, Intraventricular
Kainic Acid* / administration & dosage
Male
Rats
Rats, Inbred Strains
Seizures / chemically induced*,  physiopathology
Grant Support
ID/Acronym/Agency:
NS 17771/NS/NINDS NIH HHS; NS07018/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
40709-69-1/bicuculline methiodide; 485-49-4/Bicuculline; 487-79-6/Kainic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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