| Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide. | |
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MedLine Citation:
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PMID: 3743707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intracerebroventricular kainic acid produces in rats brain lesions similar to Ammon's horn sclerosis in humans. To test the hypothesis that these lesions result indirectly from prolonged seizure activity and not from a direct action of kainic acid on the neurons that are destroyed, the effects of intracerebroventricular kainic acid and bicuculline methiodide were compared. Although bicuculline methiodide seizures differed dramatically from kainic acid seizures, both electrographically and behaviorally, the resulting brain lesions were similar for a given total limbic seizure duration. These results, in combination with other data, support the view that lesions made by intracerebroventricular administration of convulsants are indeed caused by prolonged limbic seizures. The total duration of seizure activity appears to be one important variable. |
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Authors:
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M Gruenthal; D R Armstrong; B Ault; J V Nadler |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Experimental neurology Volume: 93 ISSN: 0014-4886 ISO Abbreviation: Exp. Neurol. Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1986-10-07 Completed Date: 1986-10-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370712 Medline TA: Exp Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 621-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bicuculline / administration & dosage, analogs & derivatives* Brain Diseases / chemically induced*, physiopathology Hippocampus / physiopathology Injections, Intraventricular Kainic Acid* / administration & dosage Male Rats Rats, Inbred Strains Seizures / chemically induced*, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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NS 17771/NS/NINDS NIH HHS; NS07018/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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40709-69-1/bicuculline methiodide; 485-49-4/Bicuculline; 487-79-6/Kainic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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