Document Detail

Comparison of segmentation methods for MRI measurement of cardiac function in rats.
MedLine Citation:
PMID:  20882617     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To establish the accuracy, intra- and inter-observer variabilities of four different segmentation methods for measuring cardiac functional parameters in healthy and infarcted rat hearts.
MATERIALS AND METHODS: Six Wistar rats were imaged before and after myocardial infarction using an electrocardiogram and respiratory-gated spoiled gradient echo sequence. Blinded and randomized datasets were analyzed by various semi-automatic and manual segmentation methods to compare their measurement bias and variability. In addition, the accuracy of these methods was assessed by comparison with reference measurements acquired from high-resolution three-dimensional (3D) datasets of a heart phantom.
RESULTS: Relative inter- and intra-observer variability were found to be similar for all four methods. Semi-automatic segmentation methods reduced analysis time by up to 70%, while yielding similar measurement bias and variability compared with manual segmentation. Semi-automatic methods were found to underestimate the ejection fraction for healthy hearts compared with manual segmentation while overestimating them in infarcted hearts. However, semi-automatic segmentation of short axis slices agreed better with 3D reference scans of a heart phantom compared with manual segmentation.
CONCLUSION: Semi-automatic segmentation methods are faster than manual segmentation, while offering a similar intra- and inter-observer variability. However, a potential bias has been observed between healthy and infarcted hearts for different methods, which should also be considered when selecting the most appropriate analysis technique.
Johannes Riegler; King K Cheung; Yiu Fung Man; Jon O Cleary; Anthony N Price; Mark F Lythgoe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  32     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-30     Completed Date:  2011-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  869-77     Citation Subset:  IM    
Centre for Advanced Biomedical Imaging (CABI), Department of Medicine and Institute of Child Health, University College London (UCL), London, United Kingdom.
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MeSH Terms
Electrocardiography / methods
Heart / physiology*
Image Processing, Computer-Assisted
Magnetic Resonance Imaging / methods*
Magnetic Resonance Imaging, Cine / methods*
Myocardial Infarction / diagnosis*,  pathology*
Myocardium / pathology*
Observer Variation
Phantoms, Imaging
Rats, Wistar
Reproducibility of Results
Grant Support
//Biotechnology and Biological Sciences Research Council; //British Heart Foundation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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