Document Detail

Comparison of same-day protocols using technetium-99m-sestamibi myocardial imaging.
MedLine Citation:
PMID:  1531069     Owner:  NLM     Status:  MEDLINE    
Two same-day protocols (rest/exercise [Protocol 1] and exercise/rest [Protocol 2]) with sestamibi (hexakis 2-methoxy-2-isobutyl-isonitrile) were performed within 2 to 14 days of each other after randomization. The initial study in each protocol was done using a dose of 185-296 MBq of 99mTc-sestamibi. The second study in each protocol used a dose of 555-925 MBq. SPECT imaging was started 30 to 60 min after injection using a 180 degrees anterior arc. Segmental analysis was interpreted as normal, scar or ischemia (20 segments/patient). Among the protocols, there was concordance in 93% of the segments (593/640 segments). In the 11 patients with coronary artery disease and no prior myocardial infarction who had ischemic abnormality, count densities from abnormal and normal zones were compared between the two protocols. Protocol 1 showed greater count differences between abnormal and normal zones on exercise images with better normalization of abnormality on rest images than Protocol 2 (p less than 0.05). Technetium-99m-sestamibi provides high quality images using either of the two same-day protocols. However, the rest/exercise protocol provides better image contrast and ability to detect reversibility of perfusion defects, and is the preferred same-day protocol.
J Heo; J Kegel; A S Iskandrian; V Cave; B B Iskandrian
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  33     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-02-21     Completed Date:  1992-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  186-91     Citation Subset:  IM    
Philadelphia Heart Institute, Presbyterian Medical Center of Philadelphia, Pennsylvania 19104.
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MeSH Terms
Ambulatory Care
Clinical Protocols
Coronary Disease / radionuclide imaging*
Exercise Test
Feasibility Studies
Middle Aged
Organotechnetium Compounds / diagnostic use*
Technetium Tc 99m Sestamibi
Reg. No./Substance:
0/Organotechnetium Compounds; 109581-73-9/Technetium Tc 99m Sestamibi

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