| Comparison of the safety and efficacy of paclitaxel plus gemcitabine combination in young and elderly patients with locally advanced or metastatic non-small cell lung cancer. A retrospective analysis of the Southern Italy Cooperative Oncology Group trials. | |
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MedLine Citation:
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PMID: 17702595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We retrospectively assessed tolerability and efficacy of paclitaxel plus gemcitabine combination in 259 patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) enrolled in three randomized SICOG trials according to their age (<or=70 or >70 years) at study entry. Apart from age, demographic and clinical characteristics were similar in the two groups. Response rate of paclitaxel plus gemcitabine was similar in younger and in elderly (36% versus 30%). Chemotherapy was well tolerated, but severe neutropenia (12% versus 7%), anaemia (6.6% versus 1.8%), and vomiting (5% versus 0) were more frequent in elderly patients. Both median progression-free survival (PFS, 5.5 months versus 4.2 months), and overall survival (OS, 11.1 months versus 9.1 months) resulted slightly prolonged for younger patients. However, only stage and performance status resulted independently affecting PFS and OS. In conclusion, paclitaxel plus gemcitabine were similarly tolerated and active in younger and elderly patients. This regimen should be considered an option for the management of fit elderly patients. |
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Authors:
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Pasquale Comella; Antonio Gambardella; Giuseppe Frasci; Antonio Avallone; Raffaele Costanzo; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2007-08-16 |
Journal Detail:
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Title: Critical reviews in oncology/hematology Volume: 65 ISSN: 1040-8428 ISO Abbreviation: Crit. Rev. Oncol. Hematol. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-07 Completed Date: 2008-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8916049 Medline TA: Crit Rev Oncol Hematol Country: Ireland |
Other Details:
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Languages: eng Pagination: 164-71 Citation Subset: IM |
Affiliation:
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Division of Medical Oncology A, Department of Medical Oncology, National Tumor Institute, Via M. Semmola, 80131 Naples, Italy. pasqualecomella@libero.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols / adverse effects, therapeutic use* Carcinoma, Non-Small-Cell Lung / drug therapy*, pathology, secondary Deoxycytidine / administration & dosage, adverse effects, analogs & derivatives* Disease-Free Survival Drug Toxicity Female Humans Italy Lung Neoplasms / drug therapy*, pathology, secondary Male Middle Aged Paclitaxel / administration & dosage*, adverse effects Retrospective Studies Survival Rate |
| Chemical | |
Reg. No./Substance:
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103882-84-4/gemcitabine; 33069-62-4/Paclitaxel; 951-77-9/Deoxycytidine |
| Investigator | |
Investigator/Affiliation:
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P Comella / ; G Frasci / ; A Avallone / ; R Costanzo / ; A Gambardella / ; M Bianco / ; D Bilancia / ; F Buzzi / ; R Bartolucci / ; R Cioffi / ; V Messina / ; P Carnicelli / ; G De Cataldis / ; F Del Gaizo / ; S Del Prete / ; L Di Lullo / ; A Farris / ; C Putzu / ; G Filippelli / ; V Olivito / ; G Dima / ; M Guida / ; A Iannelli / ; G Condemi / ; S Mancarella / ; L Maiorino / ; M Musicò / ; B Massidda / ; M T Ionta / ; E Mereu / ; P Masullo / ; D Muci / ; A Paccagnella / ; N Panza / ; S Palmeri / ; M Vaglica / ; M Roselli / ; S Mariotti / ; V Milia / ; D Natale / ; M Ghiani / ; E Barbato / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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