| Comparison of the safety and efficacy of once-daily terazosin versus twice-daily prazosin for the treatment of mild to moderate hypertension. | |
| | |
MedLine Citation:
|
PMID: 2872809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In a multicenter, double-blind, placebo-controlled study, the efficacy and safety of terazosin and prazosin were compared in patients with mild to moderate essential hypertension. Patients were randomly assigned to one of three treatment groups: terazosin administered once daily, prazosin administered twice daily, or placebo. After a two-week placebo lead-in period, each patient received increasing doses of terazosin or prazosin at two-week intervals until the supine diastolic blood pressure was decreased by 7 mm Hg or more compared with baseline, or until the maximum dose was reached. Patients in the placebo treatment group were similarly "titrated." A patient continued taking the selected dose for the remainder of the 14-week study. A total of 174 patients entered the active treatment period of the study; 155 were included in the efficacy analysis. Once-daily administration of terazosin resulted in significant (p less than or equal to 0.05) decreases in supine and standing diastolic blood pressure (-7.6 mm Hg and -8.3 mm Hg, respectively) when compared with placebo (-4.1 mm Hg and -2.2 mm Hg). The mean decrease in supine diastolic blood pressure resulting from twice-daily administration of prazosin (-4.9 mm Hg) was not significant when compared with placebo, whereas the decrease in mean standing diastolic blood pressure observed in the prazosin-treated group (-6.1 mm Hg) was significantly greater than that observed with placebo. Similar numbers of patients in all three groups reported adverse experiences of a subjective nature. In conclusion, once-daily administration of terazosin appears to be as safe and at least as effective as twice-daily administration of prazosin for the treatment of mild to moderate hypertension. |
| | |
Authors:
|
G Deger |
Related Documents
:
|
336379 - Long term effect of timolol and hydrochlorothiazide, or hydrochlorothiazide and amilori... 2131899 - Adrenergic response to nicardipine in the management of postoperative hypertension. 18034989 - Antihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patien... 11212959 - Usefulness of home blood pressure measurements in assessing the effect of treatment in ... 1827009 - Effect of isradipine on 24-h blood pressure profile demonstrated by repeated monitoring. 16679299 - Lercanidipine and losartan effects on blood pressure and fibrinolytic parameters. 7434209 - Increased oxygen uptake following phlebotomy and simultaneous fluid replacement in poly... 7427599 - Diuretic treatment of resistant hypertension. 21567219 - Percutaneous renal denervation for the treatment of resistant essential hypertension; t... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: The American journal of medicine Volume: 80 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1986 May |
Date Detail:
|
Created Date: 1986-06-27 Completed Date: 1986-06-27 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 62-7 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic alpha-Antagonists
/
administration & dosage*,
adverse effects Adult Aged Blood Pressure / drug effects Body Weight / drug effects Clinical Trials as Topic Double-Blind Method Drug Administration Schedule Female Humans Hypertension / drug therapy*, physiopathology Male Middle Aged Piperazines / administration & dosage*, adverse effects, pharmacology Posture Prazosin / administration & dosage*, adverse effects, pharmacology Pulse / drug effects Random Allocation |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic alpha-Antagonists; 0/Piperazines; 19216-56-9/Prazosin; 63590-64-7/Terazosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Experience with terazosin administered in combination with other antihypertensive agents.
Next Document: Long-term experience with terazosin for treatment of mild to moderate hypertension.