Document Detail

Comparison of the safety and efficacy of once-daily terazosin versus twice-daily prazosin for the treatment of mild to moderate hypertension.
MedLine Citation:
PMID:  2872809     Owner:  NLM     Status:  MEDLINE    
In a multicenter, double-blind, placebo-controlled study, the efficacy and safety of terazosin and prazosin were compared in patients with mild to moderate essential hypertension. Patients were randomly assigned to one of three treatment groups: terazosin administered once daily, prazosin administered twice daily, or placebo. After a two-week placebo lead-in period, each patient received increasing doses of terazosin or prazosin at two-week intervals until the supine diastolic blood pressure was decreased by 7 mm Hg or more compared with baseline, or until the maximum dose was reached. Patients in the placebo treatment group were similarly "titrated." A patient continued taking the selected dose for the remainder of the 14-week study. A total of 174 patients entered the active treatment period of the study; 155 were included in the efficacy analysis. Once-daily administration of terazosin resulted in significant (p less than or equal to 0.05) decreases in supine and standing diastolic blood pressure (-7.6 mm Hg and -8.3 mm Hg, respectively) when compared with placebo (-4.1 mm Hg and -2.2 mm Hg). The mean decrease in supine diastolic blood pressure resulting from twice-daily administration of prazosin (-4.9 mm Hg) was not significant when compared with placebo, whereas the decrease in mean standing diastolic blood pressure observed in the prazosin-treated group (-6.1 mm Hg) was significantly greater than that observed with placebo. Similar numbers of patients in all three groups reported adverse experiences of a subjective nature. In conclusion, once-daily administration of terazosin appears to be as safe and at least as effective as twice-daily administration of prazosin for the treatment of mild to moderate hypertension.
G Deger
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of medicine     Volume:  80     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-06-27     Completed Date:  1986-06-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  62-7     Citation Subset:  AIM; IM    
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MeSH Terms
Adrenergic alpha-Antagonists / administration & dosage*,  adverse effects
Blood Pressure / drug effects
Body Weight / drug effects
Clinical Trials as Topic
Double-Blind Method
Drug Administration Schedule
Hypertension / drug therapy*,  physiopathology
Middle Aged
Piperazines / administration & dosage*,  adverse effects,  pharmacology
Prazosin / administration & dosage*,  adverse effects,  pharmacology
Pulse / drug effects
Random Allocation
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Piperazines; 19216-56-9/Prazosin; 63590-64-7/Terazosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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