Document Detail

Comparison of right ventricular longitudinal strain imaging, tricuspid annular plane systolic excursion, and cardiac biomarkers for early diagnosis of cardiac involvement and risk stratification in primary systematic (AL) amyloidosis: a 5-year cohort study.
MedLine Citation:
PMID:  22307866     Owner:  NLM     Status:  MEDLINE    
AIMS: To determine the role of assessing right ventricular (RV) function, using standard echocardiography and Doppler myocardial imaging (DMI), in the early diagnosis of cardiac amyloidosis and in the prediction of mortality.
METHODS AND RESULTS: Patients with primary systemic (AL) amyloidosis seen at our institution from 1 February 2004 through 31 October 2005 (N=249) were categorized by left ventricular thickness and E' velocity and compared with 38 age- and sex-matched controls. Standard echocardiographic and DMI examination were used to measure echocardiographic parameters of RV function: systolic tissue velocity, strain rate, and strain were determined for basal and middle RV free wall segments. Patients were followed up for the endpoint of mortality. RV tricuspid annular plane systolic excursion (TAPSE) and all DMI measurements were lower in patients with AL amyloidosis and normal echocardiography results (AL-normal-echo group) than controls. A bivariate model including strain of the basal segment of the RV free wall and TAPSE was the best for distinguishing AL-normal-echo patients from controls. Male sex [hazard ratio (HR), 2.2; P=0.005], brain natriuretic peptide levels (HR 1.4; P=0.003), troponin T levels (HR 1.6; P=0.01), pleural effusion (HR 3.6; P<0.001), E/A ratio (HR 1.3; P=0.006), RV systolic pressure (HR 1.02; P=0.01), and RV strain rate of the middle segment (HR 1.3; P=0.02) were independent predictors of death.
CONCLUSION: DMI measures of the RV can identify early impairment of cardiac function or stratify risk of death in patients with AL amyloidosis. Further studies with longer follow-up are warranted to confirm these results.
Diego Bellavia; Patricia A Pellikka; Angela Dispenzieri; Christopher G Scott; Ghormallah B Al-Zahrani; Martha Grogan; Francesco Pitrolo; Jae K Oh; Fletcher A Miller
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-03
Journal Detail:
Title:  European heart journal cardiovascular Imaging     Volume:  13     ISSN:  2047-2412     ISO Abbreviation:  Eur Heart J Cardiovasc Imaging     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-11     Completed Date:  2012-11-30     Revised Date:  2013-01-29    
Medline Journal Info:
Nlm Unique ID:  101573788     Medline TA:  Eur Heart J Cardiovasc Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  680-9     Citation Subset:  IM    
Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
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MeSH Terms
Amyloidosis / physiopathology*,  ultrasonography*
Biological Markers / analysis
Case-Control Studies
Echocardiography, Doppler*
Image Interpretation, Computer-Assisted
Middle Aged
Prospective Studies
ROC Curve
Reproducibility of Results
Risk Assessment
Statistics, Nonparametric
Survival Analysis
Tricuspid Valve / physiopathology*,  ultrasonography*
Ventricular Dysfunction, Right / physiopathology*,  ultrasonography*
Reg. No./Substance:
0/Biological Markers
Comment In:
Eur Heart J Cardiovasc Imaging. 2013 Jan;14(1):91-2
Eur Heart J Cardiovasc Imaging. 2013 Jan;14(1):91   [PMID:  23034992 ]

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