Document Detail


Comparison of rest-redistribution thallium-201 imaging and reinjection after stress-redistribution for the assessment of myocardial viability in patients with left ventricular dysfunction secondary to coronary artery disease.
MedLine Citation:
PMID:  7863985     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thallium (Tl)-201 reinjection after stress-redistribution (RI) imaging has been proven to accurately identify ischemic and viable myocardium. Quantitative Tl-201 analysis after stress has also shown viable myocardium in most mild to moderate (51% to 85% of normal uptake) irreversible Tl-201 defects. However, if the main clinical question is whether a region is viable, and not whether there is inducible ischemia, a resting protocol may be more appropriate. The aim of this study was to determine whether rest-redistribution (RD) quantitative Tl-201 single-photon emission tomographic imaging provides the same information on viable myocardium as Tl-201 RI. Thus, 15 patients (mean age 58 +/- 9 years) with chronic coronary artery disease and left ventricular dysfunction (ejection fraction 35 +/- 8%) were studied by both RI and RD Tl-201 single-photon emission tomography. Regional Tl-201 uptake was assessed quantitatively using a 16-segment model. When Tl-201 images were classified as normal/reversible (viable) or irreversible (nonviable), RI showed viable myocardium in 145 of 240 myocardial regions (60%), whereas RD showed it in 103 of 240 myocardial regions (43%). The 2 imaging protocols provided concordant information in 176 of 240 myocardial regions (73%). Among the 64 (27%) discordant regions, 53 (22%) were viable by RI and nonviable by RD, whereas 11 (5%) were viable by RD and nonviable by RI (p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
A R Galassi; G Centamore; A Fiscella; A Coppola; F Liberti; M Franco; G Palazzo; S Musumeci; A Galassi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  75     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-03-21     Completed Date:  1995-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  436-42     Citation Subset:  AIM; IM    
Affiliation:
Division of Cardiology, Cannizzaro Hospital, Catania, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure
Coronary Disease / complications,  physiopathology,  radionuclide imaging*
Exercise Test
Female
Heart / physiopathology,  radionuclide imaging*
Heart Rate
Humans
Male
Middle Aged
Thallium Radioisotopes / diagnostic use*
Tomography, Emission-Computed, Single-Photon*
Ventricular Dysfunction, Left / etiology,  physiopathology,  radionuclide imaging*
Chemical
Reg. No./Substance:
0/Thallium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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