Document Detail

Comparison of responses to novel nitric oxide donors in the feline pulmonary vascular bed.
MedLine Citation:
PMID:  11711049     Owner:  NLM     Status:  MEDLINE    
Pulmonary vascular responses to the novel diazeniumdiolate nitric oxide (NO) donors diethylamine/NO, diethylenetriamine/NO, spermine/NO, sulfite/NO, and angeli's salt, were investigated and compared in the intact-chest cat. Under conditions of controlled blood flow, when tone in the pulmonary vascular bed had been raised to a high steady level, intralobar injections of diethylamine/NO (0.3-10 microg), diethylenetriamine/NO (10-30 microg), spermine/NO (10-30 microg), sulfite/NO (10-30 microg), and angeli's salt (10-30 microg) caused dose-related decreases in lobar arterial pressure without changing left atrial pressure. In terms of relative vasodilator activity in the pulmonary vascular bed, the dose of the compounds that decreased lobar arterial pressure 4 mm Hg (ED(4) mm Hg) was significantly lower for diethylamine/NO compared to S-nitroso-N-acetylpenicillamine which was significantly less than diethylenetriamine/NO, spermine/NO, sulfite/NO, and angeli's salt. The half-life of the vasodilator responses, as measured by 50% response recovery time, to diethylamine/NO, diethylenetriamine/NO, spermine/NO, sulfite/NO, and angeli's salt was similar for doses with similar magnitudes of vasodilation, while the half-life to S-nitroso-N-acetylpenicillamine was significantly less than the diazeniumdiolate NO donors. The present data demonstrate that the diazeniumdiolate NO donors diethylamine/NO, diethylenetriamine/NO, spermine/NO, sulfite/NO, and angeli's salt have potent but relatively short-lasting vasodilator activity in the pulmonary vascular bed of the cat.
B J De Witt; J R Marrone; A D Kaye; L K Keefer; P J Kadowitz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  430     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-16     Completed Date:  2002-01-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  311-5     Citation Subset:  IM    
Department of Pharmacology SL83, Tulane University School of Medicine, New Orleans, LA 70112, USA.
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MeSH Terms
Blood Pressure / drug effects
Diethylamines / pharmacology
Dose-Response Relationship, Drug
Nitric Oxide Donors / pharmacology*
Nitrites / pharmacology
Polyamines / pharmacology
Pulmonary Artery / drug effects,  physiology
Pulmonary Circulation / drug effects*
S-Nitroso-N-Acetylpenicillamine / pharmacology
Spermine / pharmacology
Sulfites / pharmacology
Grant Support
Reg. No./Substance:
0/Diethylamines; 0/Nitric Oxide Donors; 0/Nitrites; 0/Polyamines; 0/Sulfites; 109-89-7/diethylamine; 111-40-0/diethylenetriamine; 18550-55-5/oxyhyponitrite; 71-44-3/Spermine; 79032-48-7/S-Nitroso-N-Acetylpenicillamine

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