|Comparison of the responses to drugs acting on adrenoreceptors and muscarinic receptors in human isolated corpus cavernosum and cavernous artery.|
|PMID: 3157689 Owner: NLM Status: MEDLINE|
|The contractile and relaxant effects of drugs which interact with adreno- and muscarinic receptors were investigated in isolated tissue from the human corpus cavernosum urethrae (CC) and the cavernous artery (Acc). Isolated CC preparations were contracted in a concentration-dependent fashion by noradrenaline (NA), phenylephrine and clonidine in the mentioned order of potency. Prazosin was 300 times more active than rauwolscine in inhibiting NA-induced contractions. In segments of the isolated Acc, clonidine was more potent than NA and phenylephrine, and prazosin and rauwolscine were about equieffective in inhibiting NA-induced contractions. Prazosin was more effective than rauwolscine in CC strips, and rauwolscine more effective than prazosin in Acc segments in inhibiting the noradrenergically mediated part of electrically induced contractions. Isoprenaline, prenalterol and procaterol each relaxed NA-contracted CC preparations in a concentration-dependent way; this effect was blocked by propranolol. Isoprenaline had no relaxant action in Acc segments. Neither acetylcholine (ACh) nor carbachol produced contraction in CC and Acc preparations. ACh, but particularly carbachol, had potent relaxant effects in NA-contracted CC preparations. This effect of ACh and carbachol was blocked by scopolamine. Relaxant, but less potent effects of the muscarinic receptor agonists were found in the Acc segments. It is suggested that there are important differences between penile arteries and erectile tissue proper in the response to adrenoreceptor and muscarinic receptor active drugs. The contractile effect of NA seems to be mediated mainly by alpha 1-adrenoreceptors in the CC and by alpha 2-adrenoreceptors in the Acc. It cannot be excluded that muscarinic receptor-mediated relaxation of NA-contracted CC preparations can be of importance for penile tumescence and erection.|
|H Hedlund; K E Andersson|
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|Type: Comparative Study; In Vitro; Journal Article|
|Title: Journal of autonomic pharmacology Volume: 5 ISSN: 0144-1795 ISO Abbreviation: J Auton Pharmacol Publication Date: 1985 Mar|
|Created Date: 1985-06-19 Completed Date: 1985-06-19 Revised Date: 2006-11-15|
Medline Journal Info:
|Nlm Unique ID: 8106455 Medline TA: J Auton Pharmacol Country: ENGLAND|
|Languages: eng Pagination: 81-8 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Carbachol / pharmacology
Clonidine / pharmacology
Ethanolamines / pharmacology
Isoproterenol / pharmacology
Muscle Contraction / drug effects
Muscle Relaxation / drug effects
Muscle, Smooth, Vascular / drug effects*
Norepinephrine / pharmacology
Penis / blood supply, physiology*
Phenylephrine / pharmacology
Practolol / analogs & derivatives, pharmacology
Prazosin / pharmacology
Receptors, Adrenergic / drug effects*
Receptors, Muscarinic / drug effects*
Yohimbine / pharmacology
|0/Ethanolamines; 0/Receptors, Adrenergic; 0/Receptors, Muscarinic; 146-48-5/Yohimbine; 19216-56-9/Prazosin; 4205-90-7/Clonidine; 51-41-2/Norepinephrine; 51-83-2/Carbachol; 51-84-3/Acetylcholine; 57526-81-5/Prenalterol; 59-42-7/Phenylephrine; 6673-35-4/Practolol; 72332-33-3/Procaterol; 7683-59-2/Isoproterenol|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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