Document Detail


Comparison of the renal effects of indoramin and prazosin.
MedLine Citation:
PMID:  2423789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Indoramin and prazosin are both potent and selective alpha 1 adrenoceptor antagonists. Indoramin has been reported to decrease baroreceptor sensitivity, whereas prazosin has been reported to increase it. The current studies examined the relative potencies of the two drugs in inhibiting the renal vascular alpha 1 adrenoceptor and also the renal and cardiovascular effects of these agents. The drugs were infused intravenously at rates in which they equally antagonized alpha 1-receptors. Indoramin decreased blood pressure by as much as 29 mm Hg with the doses tested and also significantly (p less than 0.05) reduced heart rate. Sodium, potassium, and water excretion, and glomerular filtration rate (GFR) were unchanged. Prazosin tended to reduce blood pressure, but the 11 mm Hg fall was not statistically significant. Heart rate increased significantly (p less than 0.05). Sodium, potassium, and water excretion decreased, with a return toward control values of urine flow but not sodium excretion with higher doses. The GFR was unchanged. The results of this study indicate that neural and endocrine factors modify direct drug effects and that indoramin and prazosin administered acutely differ in the recruitment of these reflexes.
Authors:
J W Strandhoy
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  8 Suppl 2     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1986  
Date Detail:
Created Date:  1986-07-15     Completed Date:  1986-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S151-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Dogs
Glomerular Filtration Rate / drug effects
Heart Rate / drug effects
Indoles / pharmacology*
Indoramin / pharmacology*
Intracranial Pressure / drug effects
Kidney / drug effects,  physiology*
Kinetics
Phenylephrine / pharmacology
Potassium / urine
Prazosin / pharmacology*
Sodium / urine
Chemical
Reg. No./Substance:
0/Indoles; 19216-56-9/Prazosin; 26844-12-2/Indoramin; 59-42-7/Phenylephrine; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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