Document Detail


Comparison of the relative telomere length measured in leukocytes and eleven different human tissues.
MedLine Citation:
PMID:  25428739     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The relative length of telomeres measured in peripheral blood leukocytes is a commonly used system marker for biological aging and can also be used as a biomarker of cardiovascular aging. However, to what extent the telomere length in peripheral leukocytes reflects telomere length in different organ tissues is still unclear. Therefore, we have measured relative telomere length (rTL) in twelve different human tissues (peripheral blood leukocytes, liver, kidney, heart, spleen, brain, skin, triceps, tongue mucosa, intercostal skeletal muscle, subcutaneous fat, and abdominal fat) from twelve cadavers (age range of 29 week of gestation to 88 years old). The highest rTL variability was observed in peripheral leukocytes, and the lowest variability was found in brain. We found a significant linear correlation between leukocyte rTL and both intercostal muscle (R=0.68, P<0.02) and liver rTL (R=0.60, P<0.05) only. High rTL variability was observed between different organs from one individual. Furthermore, we have shown that even slight DNA degradation (modeled by sonication of genomic DNA) leads to false rTL shortening. We conclude that the rTL in peripheral leukocytes is not strongly correlated with the rTL in different organs.
Authors:
D Dlouha; J Maluskova; I Kralova Lesna; V Lanska; J A Hubacek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  63 Suppl 3     ISSN:  1802-9973     ISO Abbreviation:  Physiol Res     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  S343-50     Citation Subset:  IM    
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