| Comparison of the relative efficacy and safety of low molecular weight heparin and unfractionated heparin for the treatment of venous thrombosis. | |
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MedLine Citation:
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PMID: 8979124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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LMWH has been compared with unfractionated heparin in the treatment of venous thrombosis. The results of a pooled analysis studies of hospitalized patients showed a significant reduction of thrombus size, p < 0.001 and in the incidence of recurrent venous thromboembolism, p < 0.001 and of major bleeding p < 0.005 in patients treated with LMWH. The pooled mortality rate at long term follow-up was also found to be lower in LMWH group. Two large randomized trials have been completed in which LMWH was administered subcutaneously on an outpatient basis and compared with the standard approach of unfractionated heparin administered by continuous intravenous infusion in hospital. In both studies the efficacy, safety and mortality in the LMWH and heparin groups were similar. |
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Authors:
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J Hirsh |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Haemostasis Volume: 26 Suppl 4 ISSN: 0301-0147 ISO Abbreviation: Haemostasis Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1997-04-29 Completed Date: 1997-04-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0371574 Medline TA: Haemostasis Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 189-98 Citation Subset: IM |
Affiliation:
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Hamilton Civic Hospitals Research Centre, Henderson General Division, Hamilton, ON, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticoagulants / therapeutic use* Double-Blind Method Enoxaparin / administration & dosage, adverse effects, therapeutic use Fibrinolytic Agents / therapeutic use* Hemorrhage / chemically induced, epidemiology Heparin / administration & dosage, adverse effects, therapeutic use* Heparin, Low-Molecular-Weight / administration & dosage, adverse effects, therapeutic use* Humans Incidence Infusions, Intravenous Injections, Subcutaneous Nadroparin / administration & dosage, adverse effects, therapeutic use Partial Thromboplastin Time Randomized Controlled Trials as Topic Recurrence Safety Thromboembolism / epidemiology, prevention & control* Thrombolytic Therapy* Thrombophlebitis / drug therapy*, mortality Warfarin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Enoxaparin; 0/Fibrinolytic Agents; 0/Heparin, Low-Molecular-Weight; 0/Nadroparin; 81-81-2/Warfarin; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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