Document Detail


Comparison of the relation of triglyceride-rich lipoproteins and muscular artery compliance in healthy women versus healthy men.
MedLine Citation:
PMID:  15842969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine whether structural features or concentrations of plasma lipoproteins are predictive of arterial compliance in healthy women versus healthy men, cohorts of 111 men and 112 women with a wide range of 10-year risks for coronary artery disease were selected using assessments based on the Framingham Heart Study. Age ranges were restricted to 35 to 69 years for men and 45 to 79 years for women. Lipid-lowering drugs or any evidence of vascular disease was cause for exclusion. Fasting lipoprotein analysis and arterial compliance measurements in thigh and calf were completed in all patients. Plasma triglyceride levels were the most powerful predictor of compliance in women. Weaker but significant relations were observed between plasma non-high-density lipoprotein cholesterol, apolipoprotein-B, and apolipoprotein-CIII. In contrast, the only significant predictor of compliance in men was body weight. Thus, the major lipid predictors of arterial stiffness in women are concentrations of triglyceride-rich lipoproteins. These results are consistent with previous findings that triglyceride measurements are more strongly related to clinical vascular events in women than in men.
Authors:
Ngoc-Anh Le; W Virgil Brown; Warren W Davis; David M Herrington; Lori Mosca; Shunichi Homma; Barry Eggleston; Howard J Willens; Jeffrey K Raines
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  95     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-21     Completed Date:  2005-06-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1049-54     Citation Subset:  AIM; IM    
Affiliation:
Atlanta Veterans Affairs Hospital and Emory University School of Medicine, Atlanta, Georgia, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure / physiology
Cardiac Output / physiology
Cardiovascular Physiological Phenomena*
Cohort Studies
Coronary Vessels / physiology
Female
Humans
Leg / blood supply,  physiopathology
Lipoproteins / blood*
Male
Middle Aged
Risk Factors
Sex Factors
Thigh / blood supply,  physiopathology
Triglycerides / blood*
Chemical
Reg. No./Substance:
0/Lipoproteins; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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