| Comparison of real-time myocardial contrast echocardiography for the assessment of myocardial viability with fluorodeoxyglucose-18 positron emission tomography and dobutamine stress echocardiography. | |
| | |
MedLine Citation:
|
PMID: 15342285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Little is known about the diagnostic value of real-time myocardial contrast echocardiography (MCE) for the assessment of myocardial viability. We compared the diagnostic accuracy of MCE with that of low-dose dobutamine stress echocardiography (DSE) and of combined technetium-99 sestamibi single-photon emission computed tomography and fluorodeoxyglucose-18 positron emission tomography and investigated whether quantitative assessment of myocardial blood flow could increase its diagnostic value. Cardiac imaging was performed with these 3 methods in 41 patients who had ischemic heart disease (ejection fraction < 40%) and were being considered for revascularization. Follow-up echocardiograms were obtained after 3 to 6 months in revascularized patients, and increased regional function served as a standard reference for assessment of myocardial viability. A control group of 25 patients who had no coronary artery disease underwent MCE to assess normal values of myocardial perfusion parameters. Recovery of myocardial function was predicted by MCE with a sensitivity of 86% and a specificity of 43%. Nuclear imaging was comparably sensitive (90%) and specific (44%), whereas low-dose DSE was similarly sensitive (83%) but more specific (76%). Normalization of myocardial signal intensity to that of the control group significantly increased the specificity of MCE from 43% to 64% and the accuracy from 73% to 81%. A combination of quantitative MCE and DSE provided the best diagnostic characteristics, with a sensitivity of 96%, a specificity of 63%, and an accuracy of 83%. Thus, MCE is useful for assessing myocardial viability. Normalization of contrast intensity to that of a reference control group is a valid approach for detection of myocardial viability and expands on information obtained from visual MCE and DSE. |
| | |
Authors:
|
Grigorios Korosoglou; Alexander Hansen; Johannes Hoffend; Goran Gavrilovic; David Wolf; Joerg Zehelein; Uwe Haberkorn; Helmut Kuecherer |
Related Documents
:
|
17853065 - Resilience and vagal tone predict cardiac recovery from acute social stress. 2413305 - Haemodynamic advantages of a combined inotropic/venodilator regimen over inotropic mono... 8141085 - Dipyridamole stress echocardiography in patients with severe left main coronary artery ... 8335835 - Comparison of the effects on arterial-ventricular coupling between phosphodiesterase in... 8879945 - Pathophysiology and initial management of the acute coronary syndromes. 9829335 - A serial echocardiographic observation of acute heart injury associated with pheochromo... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of cardiology Volume: 94 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2004 Sep |
Date Detail:
|
Created Date: 2004-09-02 Completed Date: 2004-09-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 570-6 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright 2004 Excerpta Medica, Inc. |
Affiliation:
|
Department of Department, University of Heidelberg, Germany. grigorios_korosoglou@med.uni-heidelberg.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Cell Survival / physiology* Echocardiography / methods* Echocardiography, Stress / methods Female Fluorodeoxyglucose F18 / diagnostic use Heart / physiopathology* Humans Male Middle Aged Myocardial Ischemia / physiopathology*, radionuclide imaging, ultrasonography Myocardium / cytology Predictive Value of Tests Radiopharmaceuticals / diagnostic use Technetium Tc 99m Sestamibi / diagnostic use Tomography, Emission-Computed / methods* |
| Chemical | |
Reg. No./Substance:
|
0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of enalapril and losartan on cytokines in patients with stable angina pectoris awaiting coron...
Next Document: Coronary flow reserve of the angiographically normal left anterior descending coronary artery in pat...