| Comparison of real-time microvascular abnormalities in pediatric and adult sickle cell anemia patients. | |
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MedLine Citation:
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PMID: 20872552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The conjunctival microcirculation in 14 pediatric and eight adult sickle cell anemia (SCA) patients was studied using computer-assisted intravital microscopy. The bulbar conjunctiva in SCA patients in both age groups exhibited a blanched/avascular appearance characterized by decreased vascularity. SCA patients from both age groups had many of the same abnormal morphometric [vessel diameter, vessel distribution, morphometry (shape), tortuosity, arteriole:venule (A:V) ratio, and hemosiderin deposits] and dynamic [vessel sludging/sludged flow, boxcar blood (trickled) flow, and abnormal flow velocity] abnormalities. A severity index (SI) was computed to quantify the degree of vasculopathy for comparison between groups. The severity of vasculopathy differed significantly between the pediatric and adult patients (SI: 4.2 ± 1.8 vs. 6.6 ± 2.4; P = 0.028), indicative of a lesser degree of overall severity in the pediatric patients. Specific abnormalities that were less prominent in the pediatric patients included abnormal vessel morphometry and tortuosity. Sludged flow, abnormal vessel distribution, abnormal A:V ratio, and boxcar flow appeared in high prevalence in both age groups. The results indicate that SCA microvascular abnormalities develop in childhood and the severity of vasculopathy likely progresses with age. Intervention and effective treatment/management modalities should target pediatric patients to ameliorate, slow down, or prevent progressive microvascular deterioration. |
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Authors:
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Anthony T W Cheung; Joshua W Miller; Sarah M Craig; Patricia L To; Xin Lin; Sandra L Samarron; Peter C Y Chen; Theodore Zwerdling; Ted Wun; Chin-Shang Li; Ralph Green |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: American journal of hematology Volume: 85 ISSN: 1096-8652 ISO Abbreviation: Am. J. Hematol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-26 Completed Date: 2010-12-10 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 899-901 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, CA, USA. anthony.cheung@ucdmc.ucdavis.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Anemia, Sickle Cell / physiopathology* Blood Flow Velocity Child Conjunctiva / blood supply Humans Microcirculation Microvessels / pathology*, physiopathology Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL083276-04/HL/NHLBI NIH HHS; R01 HL83276/HL/NHLBI NIH HHS; UL1-RR024146/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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