| Comparison of rats of the Fischer 344 and Long-Evans strains in their autonomic thermoregulatory response to trimethyltin administration. | |
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MedLine Citation:
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PMID: 1995925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to assess the effect of genetic strain on the acute and long-term thermoregulatory response to the neurotoxicant trimethyltin (TMT) in rats of the Long-Evans (LE) and Fischer 344 (FCH) strains. In one study basic thermoregulatory responses including colonic temperature (Tc), metabolic rate (MR), evaporative water loss (EWL), motor activity (MA), and thermal conductance (Cd) were measured in both rat strains at ambient temperatures (Ta) of 10, 28, and 37 degrees C. It was found that the LE rat has a significantly higher Tc when it is measured in their home cage. Because of its smaller body mass the FCH rat has a higher MR at all Ta values. The FCH rat also has a greater rate of EWL during exposure to a Ta of 37 degrees C. Following iv administration of 8.0 mg/kg TMT both rat strains become significantly hypothermic; however, the effect differed significantly between the strains. At 26-34 d after TMT exposure thermoregulatory responses at Ta values of 10-37 degrees C were generally similar to that of the saline controls. Overall, the LE and FCH strains of rat exhibit some distinct thermoregulatory differences in response to changes in Ta. |
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Authors:
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C J Gordon; L Fogelson |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of toxicology and environmental health Volume: 32 ISSN: 0098-4108 ISO Abbreviation: J Toxicol Environ Health Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-03-26 Completed Date: 1991-03-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7513622 Medline TA: J Toxicol Environ Health Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 141-52 Citation Subset: IM |
Affiliation:
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Neurotoxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects Body Temperature Regulation / drug effects, genetics* Body Water / metabolism Injections, Intravenous Male Motor Activity / drug effects Rats Rats, Inbred F344 / genetics Species Specificity Trimethyltin Compounds / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Trimethyltin Compounds; 1631-73-8/trimethyltin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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