Document Detail

Comparison of the rates of joint arthroplasty in patients with severe factor VIII and IX deficiency: an index of different clinical severity of the 2 coagulation disorders.
MedLine Citation:
PMID:  19357395     Owner:  NLM     Status:  MEDLINE    
Data from the Italian Hemophilia Centres were collected to perform a retrospective survey of joint arthroplasty in patients with severe hemophilia. Twenty-nine of 49 hemophilia centers reported that 328 of the 347 operations were carried out in 253 patients with severe hemophilia A (HA) and 19 in 15 patients with severe hemophilia B (HB). When results were normalized to the whole Italian hemophilia population (1770 severe HA and 319 severe HB), patients with HA had a 3-fold higher risk of undergoing joint arthroplasty (odds ratio [OR], 3.38; 95% confidence interval [CI], 1.97-5.77; P < .001). These results were confirmed after adjustment for age, HIV, hepatitis C virus (HCV), and inhibitor in a Cox regression model (HR, 2.65; 95% CI, 1.62-4.33; P < .001). The survival analysis of time to joint arthroplasty in the subset of patients with severe HA was not affected by the severity of factor VIII (FVIII) gene mutations. A systematic review of literature articles reporting joint arthroplasties in HA and HB showed that the proportion of HA patients who had undergone arthroplasties was higher than that of HB patients, in agreement with the findings in our Italian cohort. These data suggest that the 2 inherited coagulation disorders have a different severity of clinical phenotype.
Giuseppe Tagariello; Alfonso Iorio; Elena Santagostino; Massimo Morfini; Ruggero Bisson; Massimo Innocenti; Maria Elisa Mancuso; Maria Gabriella Mazzucconi; Gian Luigi Pasta; Paolo Radossi; Giuseppina Rodorigo; Cristina Santoro; Roberto Sartori; Antonio Scaraggi; Luigi Pier Solimeno; Pier Mannuccio Mannucci;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Review     Date:  2009-04-08
Journal Detail:
Title:  Blood     Volume:  114     ISSN:  1528-0020     ISO Abbreviation:  Blood     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-24     Completed Date:  2009-08-10     Revised Date:  2009-12-09    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  779-84     Citation Subset:  AIM; IM    
Transfusion Service, Hemophilia and Regional Blood Disease Centre, Castelfranco Veneto, Via Ospedale 18, Castelfranco Veneto (TV), Italy.
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MeSH Terms
Arthroplasty / statistics & numerical data*
Blood Coagulation Disorders / classification,  complications,  epidemiology,  surgery
Cohort Studies
Hemophilia A / complications,  epidemiology,  surgery*
Hemophilia B / complications,  epidemiology,  surgery*
Italy / epidemiology
Joint Diseases / complications,  epidemiology*,  etiology,  surgery*
Middle Aged
Retrospective Studies
Risk Factors
Severity of Illness Index*
Young Adult
Nicola Ciavarella / ; Lelia Valdrè / ; Roberto Targhetta / ; Chiara Biasioli / ; Daniele Vincenzi / ; Claudio Molinari / ; Elio Boeri / ; Guglielmo Mariani / ; Mario Lapecorella / ; Giovanni di Minno / ; Antonio Coppola / ; Michele Schiavulli / ; Angiola Rocino / ; Giacomo Mancuso / ; Sergio Siragusa / ; Alessandra Malato / ; Annarita Tagliaferri / ; Franca Rivolta / ; Emily Oliovecchio / ; Maura Marcucci / ; Alfredo Dragani / ; Antonino Mancino / ; Marco D'Incà / ; Giulio De Rossi / ; Matteo Luciani / ; Raffaele Landolfi / ; Gavino Piseddu / ; Pier Carla Schinco / ; Gina Rossetti / ; Giovanni Barillari / ; Giulio Feola / ; Giorgio Gandini / ; Annachiara Giuffrida / ; Giancarlo Castaman /
Comment In:
Blood. 2009 Nov 26;114(23):4907; author reply 4907-8   [PMID:  19965698 ]
Blood. 2009 Jul 23;114(4):750-1   [PMID:  19628712 ]

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