Document Detail

Comparison of ranitidine and cimetidine in the inhibition of histamine, sham-feeding, and meal-induced gastric secretion in duodenal ulcer patients.
MedLine Citation:
PMID:  6105116     Owner:  NLM     Status:  MEDLINE    
The effects of ranitidine, a new H2-receptor antagonist which does not contain an imidazole ring, and cimetidine have been determined on histamine, meal-induced gastric acid secretion, and serum gastrin levels in duodenal ulcer patients. Compared with cimetidine, ranitidine was found to be about eight times more potent an inhibitor of histamine-induced secretion and four to five times more potent an inhibitor of sham-feeding, and real feeding induced acid secretion without effecting serum gastrin levels.
S J Konturek; W Obtulowicz; N Kwiecien; E Sito; E Mikos; J Oleksy
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gut     Volume:  21     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1980 Mar 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  181-6     Citation Subset:  AIM; IM    
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MeSH Terms
Cimetidine / pharmacology*,  therapeutic use
Duodenal Ulcer / drug therapy*
Furans / pharmacology*,  therapeutic use
Gastric Juice / secretion*
Gastrins / blood
Guanidines / pharmacology*
Histamine / diagnostic use
Histamine H2 Antagonists*
Reg. No./Substance:
0/Furans; 0/Gastrins; 0/Guanidines; 0/Histamine H2 Antagonists; 51-45-6/Histamine; 51481-61-9/Cimetidine; 66357-35-5/Ranitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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