| Comparison of ranitidine and cimetidine in the inhibition of histamine, sham-feeding, and meal-induced gastric secretion in duodenal ulcer patients. | |
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MedLine Citation:
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PMID: 6105116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of ranitidine, a new H2-receptor antagonist which does not contain an imidazole ring, and cimetidine have been determined on histamine, meal-induced gastric acid secretion, and serum gastrin levels in duodenal ulcer patients. Compared with cimetidine, ranitidine was found to be about eight times more potent an inhibitor of histamine-induced secretion and four to five times more potent an inhibitor of sham-feeding, and real feeding induced acid secretion without effecting serum gastrin levels. |
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Authors:
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S J Konturek; W Obtulowicz; N Kwiecien; E Sito; E Mikos; J Oleksy |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Gut Volume: 21 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 1980 Mar |
Date Detail:
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Created Date: 1980-10-27 Completed Date: 1980-10-27 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 181-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cimetidine / pharmacology*, therapeutic use Duodenal Ulcer / drug therapy* Furans / pharmacology*, therapeutic use Gastric Juice / secretion* Gastrins / blood Guanidines / pharmacology* Histamine / diagnostic use Histamine H2 Antagonists* Humans Ranitidine |
| Chemical | |
Reg. No./Substance:
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0/Furans; 0/Gastrins; 0/Guanidines; 0/Histamine H2 Antagonists; 51-45-6/Histamine; 51481-61-9/Cimetidine; 66357-35-5/Ranitidine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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