Document Detail

Comparison of radionuclide ventriculography using SPECT and planar techniques in different cardiac conditions.
MedLine Citation:
PMID:  17579852     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Accurate assessment of ventricular function is required to optimize therapeutic management of cardiac diseases. The aim of this study was to correlate planar equilibrium multigated acquisition (MUGA) with tomographic ventriculography (SPECT) in patients with diverse volumes and wall motion abnormalities. METHODS: Eighty-three studies in 80 patients (56+/-14 years; 56% women) were classified according to ventricular dilation, wall motion abnormalities and systolic dysfunction. Left and right ventricular ejection fraction (LVEF and RVEF) and end-diastolic and end-systolic left ventricular volumes (EDV and ESV) were obtained using a commercial QBS program for SPECT. On planar acquisition, LVEF and RVEF were obtained using standard techniques and volumes were determined using the count-based method, without blood sampling. RESULTS: A. Total group: With the planar method, LVEF was 44+/-17%, RVEF 42+/-13%, left EDV 147+/-97 ml (range 31-487 ml) and left ESV 93+/-85 ml (range 15-423 ml); with SPECT the corresponding values were 40+/-20%, 49+/-16%,131+/-95 ml and 91+/-89 ml, respectively (p=NS for all but RVEF). Linear correlation was 0.845 for LVEF, 0.688 for RVEF, 0.927 for left EDV and 0.94 for left ESV, with good intra-class correlation. B. Subgroups: Global and intra-class correlations between planar imaging and SPECT were high for volumes, RVEF and LVEF in all subgroups, except in patients with normal wall motion and function, who showed smaller volumes with SPECT. The group with diffuse wall motion abnormalities had a lower EDV on SPECT. In the abnormal left ventricle, RVEF was higher with SPECT. CONCLUSION: Good correlation and agreement exist between SPECT and planar MUGA with respect to LVEF and left ventricular volumes. SPECT is useful in patients with functional abnormalities, but less reliable in those with normal small cavities. A combined technique is still necessary, and RVEF should be interpreted cautiously.
Teresa Massardo; Rodrigo Jaimovich; Hugo Lavados; Daniela Gutiérrez; J Carlos Rodríguez; J Miguel Saavedra; Rita Alay; Héctor Gatica
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2007-06-20
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  34     ISSN:  1619-7070     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-17     Completed Date:  2008-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1735-46     Citation Subset:  IM    
Medicine Department, Nuclear Medicine Section, University of Chile - Clinical Hospital, Santos Dumont 999-1E, Independencia, Santiago, Chile.
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MeSH Terms
Gated Blood-Pool Imaging / methods*
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon / methods*
Ventricular Dysfunction, Left / radionuclide imaging*

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