| Comparison of quantitative parameters in cervix cancer measured by dynamic contrast-enhanced MRI and CT. | |
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MedLine Citation:
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PMID: 20512864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cervical tumors of 38 cervix cancer patients were scanned by T(1)-weighted dynamic contrast enhanced (DCE) MRI and then by DCE-CT on the same day. Gadodiamide and iohexol were respectively used as the low-molecular-weight contrast agent in DCE-MRI and DCE-CT. Under an extended Tofts model, DCE-MRI data were analyzed using either individual arterial input functions estimated by a multiple reference tissue method or a population arterial input function by Parker et al., whereas DCE-CT data were analyzed using the arterial input function directly measured from the external iliac arteries. The derived quantitative parameters of cervical tumors were compared between DCE-MRI and DCE-CT. When using the individual multiple reference tissue method arterial input functions to analyze the DCE-MRI data, the correlation coefficients between DCE-MRI- and DCE-CT-derived parameters were, respectively, back-flux rate constant (r = 0.80), extravascular extracellular fractional volume (r = 0.73), contrast agent transfer rate (r = 0.62), and blood plasma volume (r = 0.32); when using the Parker population arterial input function, the correlation coefficients were back-flux rate constant (r = 0.79), extravascular extracellular fractional volume (r = 0.77), contrast agent transfer rate (r = 0.63), and blood plasma volume (r = 0.58). Tumor parametric maps derived by DCE-MRI and DCE-CT had very similar morphologies. However, the means of most derived quantitative parameters were significantly different between the two imaging methods. Close correlation of quantitative parameters derived from two independent imaging modalities suggests both are measuring similar tumor physiologic variables. |
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Authors:
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Cheng Yang; Walter M Stadler; Gregory S Karczmar; Michael Milosevic; Ivan Yeung; Masoom A Haider |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 63 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-23 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1601-9 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Artifacts Contrast Media* / chemistry, classification Female Gadolinium DTPA / chemistry Humans Iohexol / chemistry Magnetic Resonance Imaging* Middle Aged Tomography, X-Ray Computed* Tumor Burden Uterine Cervical Neoplasms / radiography* |
| Grant Support | |
ID/Acronym/Agency:
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R21 CA108184-01A2/CA/NCI NIH HHS; R21 CA108184-02/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 122795-43-1/gadodiamide; 66108-95-0/Iohexol; 80529-93-7/Gadolinium DTPA |
| Comments/Corrections | |
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