| Comparison of the quantitative first pass myocardial perfusion MRI with and without prospective slice tracking: comparison between breath-hold and free-breathing condition. | |
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MedLine Citation:
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PMID: 20597123 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Physiologic motion of the heart is one of the major problems of myocardial blood flow quantification using first pass perfusion-MRI method. To overcome these problems, a perfusion pulse sequence with prospective slice tracking was developed. Cardiac motion was monitored by a navigator directly positioned at heart's basis to overcome no additional underlying model calculations connecting diaphragm and cardiac motion. Additional prescans were used before the perfusion measurement to detect slice displacements caused by remaining cardiac motion between navigator and the perfusion slice readout. The pulse sequence and subsequent quantification of myocardial blood flow was tested in healthy pigs with and without prospective slice tracking under both free-breathing and breath-hold conditions. To avoid influences by residual contrast agent concentration time courses were analyzed. Median myocardial blood flow values and interquartile ranges with prospective slice tracking under free-breathing and in a breath-hold were (1.04, interquartile range = 0.58 mL/min/g) and (1.20, interquartile range = 0.59 mL/min/g), respectively. This is in agreement with published positron emission tomography values. In measurements without prospective slice tracking (1.15, interquartile range = 1.58 mL/min/g), the interquartile range is significantly (P < 0.012) larger because of residual cardiac motion. In conclusion, prospective slice tracking reduces motion-induced variations of myocardial blood flow under both during breath-hold and under conditions of free-breathing. |
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Authors:
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Dirk Ernst Johannes Cleppien; Georg Horstick; Nico Abegunewardene; Stefan Weber; Christian Ernst Müller; Axel Heimann; Karl-Friedrich Kreitner; Oliver Kempski; Laura Maria Schreiber |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 64 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1461-70 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
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Section of Medical Physics, Department of Radiology, Johannes Gutenberg University Medical Center Mainz, Mainz, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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