| Comparison of quantitative angiographically derived and measured translesion pressure and flow velocity in coronary artery disease. | |
| | |
MedLine Citation:
|
PMID: 7810483 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although quantitative coronary angiography (QCA) has been used to determine lesion severity, angiographically derived parameters of translesional physiology have not been compared with those directly measured in the same patients. Thus, the aim of this study was to correlate QCA-derived translesional pressure and flow data with directly measured data in patients. QCA (DCI-ACA program), translesional pressure gradient (2.2Fr fluid-filled tracking catheter), and intracoronary Doppler flow velocity (0.018-inch FloWire) measurements were simultaneously performed in 28 arteries (25 patients). Mean diameter stenosis was 51 +/- 2.3% (range 29 to 73). No patient had left ventricular hypertrophy or valvular heart disease. The arteries studied were left anterior descending in 14, circumflex in 8, and right coronary in 6 patients. Stenotic flow reserve and baseline and maximal gradients were calculated by the DCI program. Coronary flow reserve and baseline and maximal hyperemic gradients were also directly measured distal to the stenosis after administration of intracoronary adenosine (12 to 18 micrograms). QCA-derived pressure gradients did not correlate with the measured gradients at baseline (r2 = 0.005; p = 0.73) or at maximal hyperemia (r2 = 0.1; p = 0.13). No correlation was found between the QCA-predicted flow reserve and the coronary flow reserve measured distal to the stenosis (r2 = 0.02; p = 0.46). Furthermore, stenotic flow reserve and measured gradient were not significantly correlated (r2 = 0.1; p = 0.16). In this range of stenoses of intermediate severity, there was no correlation between the measured pressure gradient or coronary flow reserve and lesion diameter or cross-sectional area by QCA.(ABSTRACT TRUNCATED AT 400 WORDS) |
| | |
Authors:
|
C Tron; M J Kern; T J Donohue; R G Bach; F V Aguirre; E A Caracciolo; J A Moore |
Related Documents
:
|
8959773 - Haemodynamic effects of descending aortic occlusion during cardiopulmonary resuscitation. 2598613 - Blood volume after coronary artery bypass grafting. 16914963 - Renin inhibition. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
|
Title: The American journal of cardiology Volume: 75 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1995 Jan |
Date Detail:
|
Created Date: 1995-02-02 Completed Date: 1995-02-02 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 111-7 Citation Subset: AIM; IM |
Affiliation:
|
Department of Internal Medicine, St. Louis University Hospital, Missouri. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Blood Flow Velocity Blood Pressure Coronary Angiography* Coronary Disease / physiopathology, radiography*, ultrasonography* Coronary Vessels / physiopathology, ultrasonography* Female Hemodynamics Humans Male Middle Aged Reproducibility of Results Ultrasonography, Doppler Ultrasonography, Interventional* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Drug treatment of insomnia: indications and newer agents.
Next Document: Diagnostic accuracy of heart rate-adjusted ST segments compared with standard ST-segment criteria.