Document Detail


Comparison of quantitative angiographic parameters with the magnitude of neointimal hyperplasia measured by volumetric intravascular ultrasound in patients treated with bare metal and nonpolymeric paclitaxel-coated stents.
MedLine Citation:
PMID:  15619403     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used data from the ASian Paclitaxel-Eluting Stent Clinical Trial (a 3-center, randomized, placebo-controlled trial of nonpolymeric paclitaxel-coated stents with a single-center intravascular ultrasound substudy) to compare angiographic indexes of drug-eluting stent efficacy with the magnitude of intimal hyperplasia (IH) assessed by intravascular ultrasound. Overall, percent IH (IH volume divided by stent volume) was larger in restenotic lesions than in nonrestenotic lesions (46 +/- 19% vs 15 +/- 13%, p <0.0001); angiographic late loss and follow-up diameter stenoses correlated strongly with percent IH.
Authors:
Gary S Mintz; Myeong-Ki Hong; Albert E Raizner; Cheol Whan Lee; Jae-Joong Kim; Esteban Escolar; Neal E Fearnot; Seong-Wook Park; Seung-Jung Park; Neil J Weissman
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  95     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-27     Completed Date:  2005-02-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of Ulsan College of Medicine, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Coronary Angiography*
Coronary Restenosis / prevention & control,  radiography*,  ultrasonography*
Coronary Vessels / pathology*,  ultrasonography*
Drug Delivery Systems*
Humans
Hyperplasia / ultrasonography
Paclitaxel / administration & dosage*
Randomized Controlled Trials as Topic
Stents*
Tunica Intima / pathology*,  ultrasonography*
Ultrasonography, Interventional*
Chemical
Reg. No./Substance:
33069-62-4/Paclitaxel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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