Document Detail


Comparison of pyritinol and auranofin in the treatment of rheumatoid arthritis. The European Multicentre Study Group.
MedLine Citation:
PMID:  8495257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy and tolerability of pyritinol (PY) and auranofin (AU) were compared in a multicentre double-blind study. Patients with RA received 600 mg/day PY or 6 mg/day AU for 1 year. Response was rated by a defined improvement in at least four of the following: Ritchie index, joint swelling index, rating scales for pain and general well-being, functional index, morning stiffness, ESR. Of the 139 fully evaluable PY patients 61 (44%) dropped out due to adverse events or response failure compared with 44 (31%) of the 142 AU patients. In patients treated for 1 year efficacy parameters improved more in the PY than in the AU group, with significant differences for the general well-being (P = 0.022), ESR (P = 0.029) and haemoglobin (P = 0.0042). The response rate for PY (61/78 patients, 78%) was significantly superior to AU (58/98 patients, 59% P = 0.009). An intention-to-treat analysis corroborated this result (P = 0.030). Adverse events (AE) occurred in 64% of PY patients and in 58% of AU patients: main AE were mucocutaneous symptoms (PY 36%, AU 23%) and gastrointestinal complaints (PY 30% AU 37%). Single cases of proteinuria, hepatic and haematological abnormalities were noted in both groups.
Authors:
E M Lemmel
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of rheumatology     Volume:  32     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-21     Completed Date:  1993-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  375-82     Citation Subset:  AIM; IM    
Affiliation:
Staatliches Rheumakrankenhaus, Baden-Baden, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Arthritis, Rheumatoid / drug therapy*
Auranofin / adverse effects,  therapeutic use*
Diarrhea / chemically induced
Double-Blind Method
Drug Eruptions / etiology
Female
Humans
Male
Middle Aged
Pyrithioxin / adverse effects,  therapeutic use*
Treatment Outcome
Chemical
Reg. No./Substance:
1098-97-1/Pyrithioxin; 34031-32-8/Auranofin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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