| Comparison of pulmonary thin section CT findings and serum KL-6 levels in patients with sarcoidosis. | |
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MedLine Citation:
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PMID: 21045068 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: This study aimed to compare thin-section CT images from sarcoidosis patients who had either normal or elevated serum KL-6 levels. Methods: 101 patients with sarcoidosis who underwent thin-section CT examinations of the chest and serum KL-6 measurements between December 2003 and November 2008 were retrospectively identified. The study group comprised 75 sarcoidosis patients (23 male, 52 female; aged 19-82 years, mean 54.1 years) with normal KL-6 levels (152-499 U ml(-1), mean 305.7 U ml(-1)) and 26 sarcoidosis patients (7 male, 19 female; aged 19-75 years, mean 54.3 years) with elevated KL-6 levels (541-2940 U ml(-1), mean 802.4 U ml(-1)). Two chest radiologists, unaware of KL-6 levels, retrospectively and independently interpreted CT images for parenchymal abnormalities, enlarged lymph nodes and pleural effusion. Results: CT findings in sarcoidosis patients consisted mainly of lymph node enlargement (70/75 with normal KL-6 levels and 21/26 with elevated KL-6 levels), followed by nodules (50 and 25 with normal and elevated levels, respectively) and bronchial wall thickening (25 and 21 with normal and elevated levels, respectively). Ground-glass opacity, nodules, interlobular septal thickening, traction bronchiectasis, architectural distortion and bronchial wall thickening were significantly more frequent in patients with elevated KL-6 levels than those with normal levels (p<0.001, p<0.005, p<0.001, p<0.001, p<0.001 and p<0.001, respectively). By comparison, there was no significant difference in frequency of lymph node enlargement between the two groups. Conclusion: These results suggest that serum KL-6 levels may be a useful marker for indicating the severity of parenchymal sarcoidosis. |
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Authors:
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K Honda; F Okada; Y Ando; H Mori; K Umeki; H Ishii; J Kadota; M Ando; E Miyazaki; T Kumamoto |
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Publication Detail:
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Type: Journal Article Date: 2010-11-02 |
Journal Detail:
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Title: The British journal of radiology Volume: 84 ISSN: 1748-880X ISO Abbreviation: Br J Radiol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: England |
Other Details:
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Languages: eng Pagination: 229-35 Citation Subset: AIM; IM |
Affiliation:
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Departments of Radiology, Oita University Faculty of Medicine, Oita, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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