Document Detail

Comparison of pulmonary CT findings and serum KL-6 levels in patients with cryptogenic organizing pneumonia.
MedLine Citation:
PMID:  19064594     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to retrospectively compare high-resolution CT findings among cryptogenic organizing pneumonia (COP) patients with normal and elevated serum KL-6 levels. Chest CT scans performed between April 1999 and April 2007 in 20 COP patients with a normal KL-6 level and 17 COP patients with an elevated KL-6 level were evaluated retrospectively by two chest radiologists. The CT findings in the COP patients with either a normal or an elevated KL-6 level mainly consisted of consolidation (n = 17 and n = 13, respectively) followed by ground-glass opacity (n = 11 and n = 13, respectively). Traction bronchiectasis and architectural distortion were significantly more frequent in patients with an elevated KL-6 level than in those with normal levels (n = 7 and n = 1, and n = 13 and n = 3, respectively) (p = 0.0077 and p = 0.00017, respectively). In follow-up CT scans, a relapse within 1 year after initial treatment with steroids, performed in 16 patients with a normal KL-6 level and 16 with an elevated KL-6 level, occurred in 2 (12.5%) patients with a normal KL-6 level and in 6 (37.5%) with an elevated KL-6 level. The frequency of relapse in patients with an elevated KL-6 level was higher than in those with a normal KL-6 level; however, no significant difference between the two groups was observed (p = 0.103). In conclusion, CT findings of traction bronchiectasis and architectural distortion in COP patients are associated with increased serum KL-6 levels, which might be related to a relapse after treatment.
F Okada; Y Ando; K Honda; S Tanoue; S Matsumoto; H Mori
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-12-08
Journal Detail:
Title:  The British journal of radiology     Volume:  82     ISSN:  1748-880X     ISO Abbreviation:  Br J Radiol     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-12     Completed Date:  2009-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  212-8     Citation Subset:  AIM; IM    
Department of Diagnostic and Interventional Radiology, Oita University Faculty of Medicine, Oita, Japan. fumitook@
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MeSH Terms
Biological Markers / metabolism
Bronchoalveolar Lavage Fluid / cytology
C-Reactive Protein / metabolism*
Cryptogenic Organizing Pneumonia / metabolism,  radiography*
Disease Progression
Lung / radiography*
Middle Aged
Mucin-1 / metabolism*
Retrospective Studies
Tomography, X-Ray Computed
Reg. No./Substance:
0/Biological Markers; 0/MUC1 protein, human; 0/Mucin-1; 9007-41-4/C-Reactive Protein

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