| Comparison of pulmonary CT findings and serum KL-6 levels in patients with cryptogenic organizing pneumonia. | |
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MedLine Citation:
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PMID: 19064594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to retrospectively compare high-resolution CT findings among cryptogenic organizing pneumonia (COP) patients with normal and elevated serum KL-6 levels. Chest CT scans performed between April 1999 and April 2007 in 20 COP patients with a normal KL-6 level and 17 COP patients with an elevated KL-6 level were evaluated retrospectively by two chest radiologists. The CT findings in the COP patients with either a normal or an elevated KL-6 level mainly consisted of consolidation (n = 17 and n = 13, respectively) followed by ground-glass opacity (n = 11 and n = 13, respectively). Traction bronchiectasis and architectural distortion were significantly more frequent in patients with an elevated KL-6 level than in those with normal levels (n = 7 and n = 1, and n = 13 and n = 3, respectively) (p = 0.0077 and p = 0.00017, respectively). In follow-up CT scans, a relapse within 1 year after initial treatment with steroids, performed in 16 patients with a normal KL-6 level and 16 with an elevated KL-6 level, occurred in 2 (12.5%) patients with a normal KL-6 level and in 6 (37.5%) with an elevated KL-6 level. The frequency of relapse in patients with an elevated KL-6 level was higher than in those with a normal KL-6 level; however, no significant difference between the two groups was observed (p = 0.103). In conclusion, CT findings of traction bronchiectasis and architectural distortion in COP patients are associated with increased serum KL-6 levels, which might be related to a relapse after treatment. |
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Authors:
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F Okada; Y Ando; K Honda; S Tanoue; S Matsumoto; H Mori |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-12-08 |
Journal Detail:
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Title: The British journal of radiology Volume: 82 ISSN: 1748-880X ISO Abbreviation: Br J Radiol Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-12 Completed Date: 2009-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: England |
Other Details:
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Languages: eng Pagination: 212-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Diagnostic and Interventional Radiology, Oita University Faculty of Medicine, Oita, Japan. fumitook@ med.oita-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Markers / metabolism Bronchoalveolar Lavage Fluid / cytology C-Reactive Protein / metabolism* Cryptogenic Organizing Pneumonia / metabolism, radiography* Disease Progression Female Humans Lung / radiography* Male Middle Aged Mucin-1 / metabolism* Retrospective Studies Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/MUC1 protein, human; 0/Mucin-1; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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