Document Detail

Comparison of protocols efficacy in poor responders: differences in oocytes/embryos competence with different protocols, a retrospective study.
MedLine Citation:
PMID:  18706554     Owner:  NLM     Status:  MEDLINE    
At present, there is no agreement on poor ovarian response definition, and no definitive evidence that this prognosis can be changed by a specific protocol. Our data suggest that a flare-up protocol with a depot gonadotropin-releasing hormone (GnRH) agonist formulation gives higher total pregnancy and implantation rates than a GnRH antagonist, possibly by improving oocyte/embryo competence.
Massimo Manno; Francesco Tomei; Marta Cervi; Cristina Favretti; Valter Adamo
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-08-15
Journal Detail:
Title:  Fertility and sterility     Volume:  91     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-06     Completed Date:  2009-04-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1431-3     Citation Subset:  IM    
Maternal-Pediatric Department, Pordenone Hospital, Pathophysiology Unit of Human Reproduction and Sperm Bank, Pordenone, Italy.
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MeSH Terms
Chorionic Gonadotropin / pharmacology
Clinical Protocols*
Dose-Response Relationship, Drug
Embryo Transfer
Embryonic Development / physiology*
Gonadotropin-Releasing Hormone / agonists*,  antagonists & inhibitors*
Luteolytic Agents / pharmacology
Oocytes / drug effects,  physiology*
Ovulation Induction / methods*
Pregnancy Rate
Retrospective Studies
Sperm Injections, Intracytoplasmic
Triptorelin / pharmacology
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Luteolytic Agents; 33515-09-2/Gonadotropin-Releasing Hormone; 57773-63-4/Triptorelin

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