Document Detail

Comparison of prostate IMRT and VMAT biologically optimised treatment plans.
MedLine Citation:
PMID:  20801014     Owner:  NLM     Status:  MEDLINE    
Recently, a new radiotherapy delivery technique has become clinically available--volumetric modulated arc therapy (VMAT). VMAT is the delivery of IMRT while the gantry is in motion using dynamic leaf motion. The perceived benefit of VMAT over IMRT is a reduction in delivery time. In this study, VMAT was compared directly with IMRT for a series of prostate cases. For 10 patients, a biologically optimized seven-field IMRT plan was compared with a biologically optimized VMAT plan using the same planning objectives. The Pinnacle RTPS was used. The resultant target and organ-at-risk dose-volume histograms (DVHs) were compared. The normal tissue complication probability (NTCP) for the IMRT and VMAT plans was calculated for 3 model parameter sets. The delivery efficiency and time for the IMRT and VMAT plans was compared. The VMAT plans resulted in a statistically significant reduction in the rectal V25Gy parameter of 8.2% on average over the IMRT plans. For one of the NTCP parameter sets, the VMAT plans had a statistically significant lower rectal NTCP. These reductions in rectal dose were achieved using 18.6% fewer monitor units and a delivery time reduction of up to 69%. VMAT plans resulted in reductions in rectal doses for all 10 patients in the study. This was achieved with significant reductions in delivery time and monitor units. Given the target coverage was equivalent, the VMAT plans were superior.
Nicholas Hardcastle; Wolfgang A Tomé; Kerwyn Foo; Andrew Miller; Martin Carolan; Peter Metcalfe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-08-30
Journal Detail:
Title:  Medical dosimetry : official journal of the American Association of Medical Dosimetrists     Volume:  36     ISSN:  1873-4022     ISO Abbreviation:  Med Dosim     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-02     Completed Date:  2011-11-28     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  8908862     Medline TA:  Med Dosim     Country:  United States    
Other Details:
Languages:  eng     Pagination:  292-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Prostatic Neoplasms / radiotherapy*
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted*
Radiotherapy, Intensity-Modulated*
Grant Support
R01 CA106835/CA/NCI NIH HHS; R01 CA106835-03/CA/NCI NIH HHS; R01-CA106835/CA/NCI NIH HHS

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