Document Detail

Comparison of prostanoids and their precursor fatty acids in human hepatocellular carcinoma and noncancerous reference tissues.
MedLine Citation:
PMID:  8094103     Owner:  NLM     Status:  MEDLINE    
Eicosanoid production and the compositions of precursor fatty acids were determined in human cancerous and reference liver tissues. Seventeen hepatectomized cases (12 cases of hepatocellular carcinoma (HCC) and 5 cases of metastatic liver cancer) were evaluated. The cancerous tissues and the noncancerous reference tissues were separated, lipids were extracted, and the fatty acids were determined as methyl esters by gas chromatography. Prostanoids (6-keto PGF1 alpha and TXB2) were measured by radioimmunoassay. In HCC, the levels of alpha-linolenic acid (omega-3) (0.41 +/- 0.38 x 100 micrograms/g) and docosahexaenoic acid (10.41 +/- 4.96 x 100 micrograms/g) in liver cancer tissue were significantly less than those in the reference tissues. In HCC, the levels of TXB2 reference (1.86 +/- 2.77 pg/mg wet weight) and 6-keto PGF1 alpha were 10-fold higher than those in reference tissues. We speculate that in HCC higher prostanoid levels in the liver are related in part to tumor metabolism.
T Hanai; T Hashimoto; K Nishiwaki; M Ono; Y Akamo; M Tanaka; I Mizuno; J Yura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of surgical research     Volume:  54     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-03-11     Completed Date:  1993-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  57-60     Citation Subset:  IM    
First Department of Surgery, Nagoya City University Medical School, Japan.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / metabolism
Carcinoma, Hepatocellular / metabolism*,  surgery
Docosahexaenoic Acids / metabolism
Eicosanoids / metabolism*
Fatty Acids / metabolism*
Linolenic Acids / metabolism
Liver Neoplasms / metabolism*,  surgery
Middle Aged
Thromboxane B2 / metabolism
alpha-Linolenic Acid
Reg. No./Substance:
0/Eicosanoids; 0/Fatty Acids; 0/Linolenic Acids; 25167-62-8/Docosahexaenoic Acids; 463-40-1/alpha-Linolenic Acid; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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