Document Detail


Comparison of prostanoids and their precursor fatty acids in human hepatocellular carcinoma and noncancerous reference tissues.
MedLine Citation:
PMID:  8094103     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eicosanoid production and the compositions of precursor fatty acids were determined in human cancerous and reference liver tissues. Seventeen hepatectomized cases (12 cases of hepatocellular carcinoma (HCC) and 5 cases of metastatic liver cancer) were evaluated. The cancerous tissues and the noncancerous reference tissues were separated, lipids were extracted, and the fatty acids were determined as methyl esters by gas chromatography. Prostanoids (6-keto PGF1 alpha and TXB2) were measured by radioimmunoassay. In HCC, the levels of alpha-linolenic acid (omega-3) (0.41 +/- 0.38 x 100 micrograms/g) and docosahexaenoic acid (10.41 +/- 4.96 x 100 micrograms/g) in liver cancer tissue were significantly less than those in the reference tissues. In HCC, the levels of TXB2 reference (1.86 +/- 2.77 pg/mg wet weight) and 6-keto PGF1 alpha were 10-fold higher than those in reference tissues. We speculate that in HCC higher prostanoid levels in the liver are related in part to tumor metabolism.
Authors:
T Hanai; T Hashimoto; K Nishiwaki; M Ono; Y Akamo; M Tanaka; I Mizuno; J Yura
Related Documents :
21952113 - Interaction of the retinoic acid signaling pathway with spicule formation in the marine...
1203753 - Effect of valine on the control of fatty acid synthesis in white adipose tissue of the ...
7771493 - Renal hypouricemia: prevention of exercise-induced acute renal failure and a review of ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of surgical research     Volume:  54     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-03-11     Completed Date:  1993-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  57-60     Citation Subset:  IM    
Affiliation:
First Department of Surgery, Nagoya City University Medical School, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
6-Ketoprostaglandin F1 alpha / metabolism
Aged
Carcinoma, Hepatocellular / metabolism*,  surgery
Docosahexaenoic Acids / metabolism
Eicosanoids / metabolism*
Fatty Acids / metabolism*
Female
Hepatectomy
Humans
Linolenic Acids / metabolism
Liver Neoplasms / metabolism*,  surgery
Male
Middle Aged
Thromboxane B2 / metabolism
alpha-Linolenic Acid
Chemical
Reg. No./Substance:
0/Eicosanoids; 0/Fatty Acids; 0/Linolenic Acids; 25167-62-8/Docosahexaenoic Acids; 463-40-1/alpha-Linolenic Acid; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Secretin receptors in a new preparation of plasma membranes from intrahepatic biliary epithelium.
Next Document:  Expression of P-glycoprotein and anionic glutathione S-transferase genes in non-Hodgkin's lymphoma.