Document Detail

Comparison of propranolol, sotalol, and betaxolol in the treatment of neuroleptic-induced akathisia.
MedLine Citation:
PMID:  2884889     Owner:  NLM     Status:  MEDLINE    
In earlier open studies, beta-blockers were found to be effective in the treatment of neuroleptic-induced akathisia. In the present study, 16 patients with severe neuroleptic-induced akathisia successively received low doses of three beta-blockers--propranolol, sotalol, and betaxolol. There was rapid and complete improvement in seven of 16 patients (and partial improvement in three patients) treated with betaxolol. The efficacy of propranolol and betaxolol and failure of sotalol in treating neuroleptic-induced akathisia suggest a central mechanism of action.
B Dupuis; J Catteau; J P Dumon; C Libert; H Petit
Related Documents :
17207719 - Influence of blood pressure on the effectiveness of a fixed-dose combination of isosorb...
22503099 - Laser-assisted nasal decolonization of staphylococcus aureus, including methicillin-res...
16051519 - Short- and long-term results of a programme for the prevention of readmissions and mort...
8590529 - Inotropic therapy for the failing myocardium.
15642809 - Bronchial reactivity in healthy individuals undergoing long-term topical treatment with...
9507679 - Copd: results of long-term treatment.
11768639 - Blood loss in anterior cruciate ligament (acl) reconstruction with and without intercon...
23680949 - Learning curve for transoral robotic surgery: a 4-year analysis.
6365349 - Nifedipine and conventional therapy for unstable angina pectoris: a randomized, double-...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  144     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-07-01     Completed Date:  1987-07-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  802-5     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Akathisia, Drug-Induced
Antipsychotic Agents / adverse effects*
Clinical Trials as Topic
Dose-Response Relationship, Drug
Middle Aged
Propanolamines / administration & dosage,  therapeutic use*
Propranolol / administration & dosage,  therapeutic use*
Psychomotor Agitation / drug therapy*
Sotalol / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Antipsychotic Agents; 0/Propanolamines; 3930-20-9/Sotalol; 525-66-6/Propranolol; 63659-18-7/Betaxolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Psychological and interpersonal issues in space.
Next Document:  Rapidly progressive hearing loss as a symptom of polyarteritis nodosa.