Document Detail

Comparison of propranolol, sotalol, and betaxolol in the treatment of neuroleptic-induced akathisia.
MedLine Citation:
PMID:  2884889     Owner:  NLM     Status:  MEDLINE    
In earlier open studies, beta-blockers were found to be effective in the treatment of neuroleptic-induced akathisia. In the present study, 16 patients with severe neuroleptic-induced akathisia successively received low doses of three beta-blockers--propranolol, sotalol, and betaxolol. There was rapid and complete improvement in seven of 16 patients (and partial improvement in three patients) treated with betaxolol. The efficacy of propranolol and betaxolol and failure of sotalol in treating neuroleptic-induced akathisia suggest a central mechanism of action.
B Dupuis; J Catteau; J P Dumon; C Libert; H Petit
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  144     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-07-01     Completed Date:  1987-07-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  802-5     Citation Subset:  AIM; IM    
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MeSH Terms
Akathisia, Drug-Induced
Antipsychotic Agents / adverse effects*
Clinical Trials as Topic
Dose-Response Relationship, Drug
Middle Aged
Propanolamines / administration & dosage,  therapeutic use*
Propranolol / administration & dosage,  therapeutic use*
Psychomotor Agitation / drug therapy*
Sotalol / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Antipsychotic Agents; 0/Propanolamines; 3930-20-9/Sotalol; 525-66-6/Propranolol; 63659-18-7/Betaxolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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