| Comparison of propofol and thiopentone as induction agents for laparoscopy. | |
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MedLine Citation:
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PMID: 1828309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifty two patients for laparoscopy were randomly divided into two groups and induced with propofol 2 mgkg-1 or thiopentone 4 mgkg-1. The two groups were similar for race, age, weight, premedication and duration of operation. General anaesthesia with endotracheal intubation, nitrous oxide/oxygen with 0.5% halothane and muscle relaxation with suxamethonium was used throughout. Induction times were similar for both groups. The systolic, diastolic blood pressures and heart rates of both groups fell significantly from baseline values two minutes after induction. The fall in systolic blood pressure was greater with propofol (p less than 0.01). Following intubation the rise in systolic, diastolic blood pressures and heart rate above baseline values were greater with thiopentone (p less than 0.001 for all three variables). Discomfort on injection and involuntary movements were significantly more common with propofol. Laryngospasm was significantly more common with thiopentone. Patients given propofol could sit up unaided earlier after the anaesthesia (p less than 0.01). There was no difference in eye opening and orientation time. |
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Authors:
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W K Boey; A Kumar |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Singapore medical journal Volume: 32 ISSN: 0037-5675 ISO Abbreviation: Singapore Med J Publication Date: 1991 Apr |
Date Detail:
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Created Date: 1991-07-11 Completed Date: 1991-07-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404516 Medline TA: Singapore Med J Country: SINGAPORE |
Other Details:
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Languages: eng Pagination: 150-3 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia, National University Hospital, Singapore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia Recovery Period Anesthesia, Intravenous / methods* Blood Pressure / drug effects Humans Laparoscopy* Propofol* / adverse effects, pharmacokinetics Thiopental* / adverse effects, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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2078-54-8/Propofol; 76-75-5/Thiopental |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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