Document Detail

Comparison of propofol and isoflurane anesthesia in orthotopic pig-to-baboon cardiac xenotransplantation.
MedLine Citation:
PMID:  17489866     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Orthotopic pig-to-baboon xenogeneic heart transplantation (oXHTx) is the only accepted preclinical animal model for cardiac xenotransplantation. We compared the hemodynamic stability of a propofol- and isoflurane-based anesthetic regimen during oXHTx. METHODS: Hearts from 12 hDAF or hCD46 transgenic pigs (Sus scrofa; body weight 7 to 32 kg) were transplanted into baboons (Papio anubis and Papio hamadryas; body weight 9 to 26 kg) in the orthotopic life-supporting position. Animals received a propofol-based intravenous regimen or inhalation anesthesia with isoflurane. Analgesia was achieved with fentanyl in both groups. Systemic hemodynamic variables were measured before, during and after cardiopulmonary bypass (CPB) and the need for inotropic or vasoactive pharmacological support was compared before and after CPB. RESULTS: Global hemodynamic variables [i.e. heart rate, mean arterial pressure (MAP) and cardiac output] were not significantly different in propofol-anesthetized baboons compared to baboons anesthetized with isoflurane. Baboons anesthetized with isoflurane showed a trend towards less pharmacological support required to achieve an adequate MAP of >60 mmHg after CPB (propofol: epinephrine 0.13 [0.05; 0.16] and norepinephrine 0.15 [0.02; 0.16] microg/kg/min vs. isoflurane: epinephrine 0.05 [0.02; 0.08] and norepinephrine 0.06 [0.02; 0.19] microg/kg/min; no significant difference). CONCLUSIONS: Propofol and isoflurane appear to provide equal hemodynamic stability in orthotopic cardiac pig-to-baboon xenotransplantation prior to the start of CPB. The trend of a reduced catecholamine support needed after CPB, however, suggests that isoflurane may be the preferred drug for maintenance of anesthesia in this primate model.
Andreas Bauer; Heiko Baschnegger; Vivian Renz; Ulrike Brandl; Paolo Brenner; Eckart Thein; Bruno Reichart; Michael Schmoeckel; Frank Christ
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Xenotransplantation     Volume:  14     ISSN:  0908-665X     ISO Abbreviation:  Xenotransplantation     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-10     Completed Date:  2007-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438793     Medline TA:  Xenotransplantation     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  249-54     Citation Subset:  IM    
Clinic for Anaesthesiology, Ludwig Maximilian University Munich, Munich, Germany.
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MeSH Terms
Anesthesia, General / methods,  veterinary
Anesthetics, Inhalation / pharmacology*
Anesthetics, Intravenous / pharmacology*
Blood Pressure / drug effects
Central Venous Pressure / drug effects
Disease Models, Animal
Heart Rate / drug effects
Heart Transplantation / methods*
Isoflurane / pharmacology*
Propofol / pharmacology*
Sus scrofa
Transplantation, Heterologous / methods*
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 2078-54-8/Propofol; 26675-46-7/Isoflurane

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