| Comparison of propofol-fentanyl with propofol-fentanyl-ketamine combination in pediatric patients undergoing interventional radiology procedures. | |
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MedLine Citation:
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PMID: 19453582 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: With an increase in the frequency of interventional radiology procedures in pediatrics, there has been a corresponding increase in demand for procedural sedation to facilitate them. The purpose of our study was to compare the frequency of adverse effects, sedation level, patient recovery characteristics in pediatric patients receiving intravenous propofol fentanyl combination with or without ketamine for interventional radiology procedures. Our main hypothesis was that the addition of ketamine would decrease propofol/fentanyl associated desaturation. METHODS AND MATERIALS: Sixty consenting American Society of Anesthesia physical status I-III pediatric patients undergoing interventional radiology procedures under sedation were studied according to a randomized, double-blinded, institutional review board approved protocol. Group 1 received propofol 0.5 mg.kg(-1) + fentanyl 1 microg.kg(-1) + ketamine 0.5 mg.kg(-1), and group 2 received propofol 0.5 mg.kg(-1) + fentanyl 1 microg.kg(-1) + same volume of %0.9 NaCl intravenously. RESULTS: While apnea was not observed in any of the groups, there were three cases (10%) in group 1, and nine cases (30%) in group 2 with oxygen desaturation (P = 0.052). In group 1, 12 (40%) patients and, in group 2, 21 (70%) patients required supplemental propofol during the procedure (P = 0.021). There was no evidence for difference between groups in terms of other side effects except nystagmus. CONCLUSIONS: In conclusion, addition of low dose ketamine to propofol-fentanyl combination decreased the risk of desaturation and it also decreased the need for supplemental propofol dosage in pediatric patients at interventional radiology procedures. |
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Authors:
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I Aydin Erden; A Gulsun Pamuk; Seda B Akinci; Ayhan Koseoglu; Ulku Aypar |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Paediatric anaesthesia Volume: 19 ISSN: 1460-9592 ISO Abbreviation: Paediatr Anaesth Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-20 Completed Date: 2009-07-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206575 Medline TA: Paediatr Anaesth Country: France |
Other Details:
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Languages: eng Pagination: 500-6 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology and Reanimation, Hacettepe University, Sihhiye, Ankara 06100, Turkey. aydinerden@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Analgesics / administration & dosage, adverse effects Analysis of Variance Anesthesia Recovery Period Anesthetics, Combined / administration & dosage*, adverse effects Anesthetics, Intravenous / administration & dosage, adverse effects Child Child, Preschool Double-Blind Method Female Fentanyl / administration & dosage*, adverse effects Humans Infant Ketamine / administration & dosage*, adverse effects Male Odds Ratio Oxygen / blood Propofol / administration & dosage*, adverse effects Radiology, Interventional / methods* Respiration / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Anesthetics, Combined; 0/Anesthetics, Intravenous; 2078-54-8/Propofol; 437-38-7/Fentanyl; 6740-88-1/Ketamine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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