Document Detail

Comparison of propofol-fentanyl with propofol-fentanyl-ketamine combination in pediatric patients undergoing interventional radiology procedures.
MedLine Citation:
PMID:  19453582     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: With an increase in the frequency of interventional radiology procedures in pediatrics, there has been a corresponding increase in demand for procedural sedation to facilitate them. The purpose of our study was to compare the frequency of adverse effects, sedation level, patient recovery characteristics in pediatric patients receiving intravenous propofol fentanyl combination with or without ketamine for interventional radiology procedures. Our main hypothesis was that the addition of ketamine would decrease propofol/fentanyl associated desaturation. METHODS AND MATERIALS: Sixty consenting American Society of Anesthesia physical status I-III pediatric patients undergoing interventional radiology procedures under sedation were studied according to a randomized, double-blinded, institutional review board approved protocol. Group 1 received propofol 0.5 + fentanyl 1 + ketamine 0.5, and group 2 received propofol 0.5 + fentanyl 1 + same volume of %0.9 NaCl intravenously. RESULTS: While apnea was not observed in any of the groups, there were three cases (10%) in group 1, and nine cases (30%) in group 2 with oxygen desaturation (P = 0.052). In group 1, 12 (40%) patients and, in group 2, 21 (70%) patients required supplemental propofol during the procedure (P = 0.021). There was no evidence for difference between groups in terms of other side effects except nystagmus. CONCLUSIONS: In conclusion, addition of low dose ketamine to propofol-fentanyl combination decreased the risk of desaturation and it also decreased the need for supplemental propofol dosage in pediatric patients at interventional radiology procedures.
I Aydin Erden; A Gulsun Pamuk; Seda B Akinci; Ayhan Koseoglu; Ulku Aypar
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  19     ISSN:  1460-9592     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-20     Completed Date:  2009-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  France    
Other Details:
Languages:  eng     Pagination:  500-6     Citation Subset:  IM    
Department of Anaesthesiology and Reanimation, Hacettepe University, Sihhiye, Ankara 06100, Turkey.
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MeSH Terms
Analgesics / administration & dosage,  adverse effects
Analysis of Variance
Anesthesia Recovery Period
Anesthetics, Combined / administration & dosage*,  adverse effects
Anesthetics, Intravenous / administration & dosage,  adverse effects
Child, Preschool
Double-Blind Method
Fentanyl / administration & dosage*,  adverse effects
Ketamine / administration & dosage*,  adverse effects
Odds Ratio
Oxygen / blood
Propofol / administration & dosage*,  adverse effects
Radiology, Interventional / methods*
Respiration / drug effects
Reg. No./Substance:
0/Analgesics; 0/Anesthetics, Combined; 0/Anesthetics, Intravenous; 2078-54-8/Propofol; 437-38-7/Fentanyl; 6740-88-1/Ketamine; 7782-44-7/Oxygen

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