Document Detail

Comparison of propofol and fentanyl administered at the end of anaesthesia for prevention of emergence agitation after sevoflurane anaesthesia in children.
MedLine Citation:
PMID:  23103775     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Propofol and fentanyl can be administered at the end of sevoflurane anaesthesia to decrease the incidence and severity of emergence agitation (EA), although it has not been determined which agent has superior efficacy. The purpose of this study was to compare the effects of propofol and fentanyl on EA.
METHODS: In this prospective, randomized, double-blind study, 222 children, 18-72 months of age, undergoing sevoflurane anaesthesia were randomly assigned to one of the three groups receiving either propofol 1 mg kg(-1) (Group P), fentanyl 1 µg kg(-1) (Group F), or saline (Group S) at the end of anaesthesia. The incidence and severity of EA were evaluated with the paediatric anaesthesia emergence delirium (PAED) scale. Time to recovery and incidence of nausea/vomiting were assessed.
RESULTS: The mean PAED score was 4.3 in Group P and 4.9 in Group F (P=0.682), which were lower than 9.0 in Group S (P<0.001). Nausea and vomiting were significantly more frequent in Group F than Groups P and S (adjusted P=0.003 and adjusted P<0.001). Group F had also longer stay in the post-anaesthesia care unit (PACU) than Group S (P<0.001), while Group P did not. However, the differences in PACU stays between the P and F groups were considered clinically insignificant.
CONCLUSION: Small doses of propofol or fentanyl at the end of sevoflurane anaesthesia comparably reduced EA. Propofol was better than fentanyl due to a lower incidence of nausea and vomiting.
M-S Kim; B-E Moon; H Kim; J-R Lee
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2012-10-26
Journal Detail:
Title:  British journal of anaesthesia     Volume:  110     ISSN:  1471-6771     ISO Abbreviation:  Br J Anaesth     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-15     Completed Date:  2013-03-04     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  274-80     Citation Subset:  IM    
Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
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MeSH Terms
Akathisia, Drug-Induced / prevention & control*
Analgesics, Opioid / therapeutic use*
Anesthesia Recovery Period
Anesthesia, Inhalation*
Anesthetics, Inhalation*
Child, Preschool
Double-Blind Method
Fentanyl / therapeutic use*
Hypnotics and Sedatives / therapeutic use*
Intensive Care Units, Pediatric
Methyl Ethers*
Postoperative Nausea and Vomiting / epidemiology
Propofol / therapeutic use*
Respiration, Artificial
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anesthetics, Inhalation; 0/Hypnotics and Sedatives; 0/Methyl Ethers; 2078-54-8/Propofol; 28523-86-6/sevoflurane; 437-38-7/Fentanyl
Comment In:
Br J Anaesth. 2013 Jul;111(1):121   [PMID:  23794655 ]
Br J Anaesth. 2013 Jul;111(1):121-2   [PMID:  23794654 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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