| Comparison of the prognostic value of the stress-recovery index versus standard electrocardiographic criteria in patients with a negative exercise electrocardiogram. | |
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MedLine Citation:
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PMID: 17697814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To verify whether the stress recovery index (SRI) improves risk stratification in patients with a negative exercise electrocardiogram (ECG) using standard criteria, the SRI was derived in 708 consecutive patients with a negative exercise ECG. All-cause mortality and the combination of death or nonfatal myocardial infarction were target end points. The individual effect of clinical and exercise testing data on outcome was evaluated using Cox regression analysis with separate models for each group of variables. Model validation was performed using bootstrap adjusted by degree of optimism in estimates. Survival analysis was performed using a product-limit Kaplan-Meier method. During a 37-month follow-up, 22 deaths and 40 nonfatal acute coronary syndromes occurred. After adjusting for confounding variables, age (hazard ratio 1.62, 95% confidence interval [CI] 1.14 to 2.31 for interquartile difference), hypertension (hazard ratio 1.74, 95% CI 1.04 to 2.89), and SRI (hazard ratio 0.75, 95% CI 0.65 to 0.86 for interquartile difference) were predictive of death or nonfatal myocardial infarction. Moreover, SRI increased the prognostic power of the model on top of clinical and exercise testing variables and provided significant discrimination of survival. In conclusion, the SRI may help refine the prognostic stratification of patients with a negative exercise test result using standard electrocardiographic criteria. |
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Authors:
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Riccardo Bigi; Lauro Cortigiani; Dario Gregori; Cesare Fiorentini |
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Publication Detail:
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Type: Journal Article Date: 2007-06-27 |
Journal Detail:
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Title: The American journal of cardiology Volume: 100 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-09-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 605-9 Citation Subset: AIM; IM |
Affiliation:
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Cardiology, Department of Medicine and Surgery, University School of Medicine, Milan, Italy. riccardo.bigi@unimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cause of Death Electrocardiography / methods* Exercise Test Female Follow-Up Studies Humans Italy / epidemiology Male Middle Aged Myocardial Ischemia / diagnosis, mortality, physiopathology* Outpatients Predictive Value of Tests Prognosis Retrospective Studies Severity of Illness Index Stress, Physiological / physiopathology* Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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