Document Detail

Comparison of the prognostic value of cardiopulmonary exercise testing between male and female patients with heart failure.
MedLine Citation:
PMID:  16650490     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cardiopulmonary exercise testing (CPX) clearly holds prognostic value in the heart failure (HF) population. Studies investigating the prognostic value of CPX in individuals with HF have consistently examined predominantly male groups. The purpose of the present study was to examine the prognostic value of CPX in a female HF group. METHODS: Seventy-five female and 337 male subjects diagnosed with HF participated in this study. The ability of peak oxygen consumption (VO(2)) and the minute ventilation/carbon dioxide production (VE/VCO(2)) slope to predict cardiac-related events were assessed. RESULTS: In the year following CPX, the female group suffered 26 cardiac-related events (8 deaths/18 hospitalizations), while the male group suffered 89 cardiac-related events (20 deaths/69 hospitalizations). The hazard ratios for peak VO(2) and the VE/VCO(2) slope were 4.0 (95% confidence interval: 2.6-6.1, p<0.001) and 4.2 (95% confidence interval: 2.7-6.6, p<0.001) in the male group and 3.8 (95% confidence interval: 1.7-8.5, p<0.001) and 4.3 (95% confidence interval: 1.8-9.8, p<0.001) in the female group. In both the male and female groups, Cox multivariate analysis revealed VE/VCO(2) slope was the strongest predictor of cardiac-related events while peak VO(2) added significant predictive value and was retained in the regression. CONCLUSION: The results of the present study indicate that the prognostic value of peak VO(2) and the VE/VCO(2) slope are similar in men and women diagnosed with HF. In both men and women, the prognostic power of the VE/VCO(2) slope is greater than that of peak VO(2).
Marco Guazzi; Ross Arena; Jonathan Myers
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2006-05-02
Journal Detail:
Title:  International journal of cardiology     Volume:  113     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-13     Completed Date:  2007-01-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  395-400     Citation Subset:  IM    
University of Milano, San Paolo Hospital, Cardiology Division, Italy.
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MeSH Terms
Carbon Dioxide / metabolism
Exercise Test*
Heart Failure / diagnosis*,  metabolism,  physiopathology*
Middle Aged
Oxygen / metabolism
Retrospective Studies
Sex Factors
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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