Document Detail


Comparison of production of Staphylococcus intermedius exotoxin among clinically normal dogs, atopic dogs with recurrent pyoderma, and dogs with a single episode of pyoderma.
MedLine Citation:
PMID:  9676593     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether exotoxin production by Staphylococcus intermedius is an important factor in recurrence of pyoderma in atopic dogs. DESIGN: Prospective clinical study. ANIMALS: 30 client-owned dogs (10 clinically normal dogs, 10 atopic dogs with recurrent pyoderma, and 10 dogs with a single episode of pyoderma). PROCEDURE: Specimens for bacterial culturing were obtained from a pustule or papule of affected dogs or from skin of clinically normal dogs. Staphylococcus intermedius was isolated and processed. Supernatants were analyzed for staphylococcal exotoxins. Types of lesions and severity of pruritus were assessed for each dog. RESULTS: Exotoxins A and C were detected in S intermedius isolated from 1 clinically normal dog. In the atopic group, exotoxin C was isolated from 1 dog, exotoxins A and C were isolated from 1 dog, and exotoxin C and toxic shock syndrome toxin-1 were isolated from 1 dog. Exotoxins were isolated from 2 dogs with a single episode of pyoderma (exotoxin C, 1 dog; exotoxins A and C, 1 dog). Lesion types and severity of pruritus varied greatly among dogs with pyoderma and were not associated with detection of exotoxin or type of exotoxin. CLINICAL IMPLICATIONS: Exotoxins were identified from few isolates of S intermedius, and we did not observe an association between type of lesions or severity of pruritus and detection of exotoxins. Production of exotoxin by S intermedius does not play a role in the recurrent nature of pyoderma in atopic dogs or on type of lesion or severity of pruritus associated with pyoderma.
Authors:
G Burkett; L A Frank
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Veterinary Medical Association     Volume:  213     ISSN:  0003-1488     ISO Abbreviation:  J. Am. Vet. Med. Assoc.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-08-04     Completed Date:  1998-08-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503067     Medline TA:  J Am Vet Med Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  232-4     Citation Subset:  IM    
Affiliation:
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville 37901, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dermatitis, Atopic / complications,  microbiology,  veterinary*
Dog Diseases / microbiology*
Dogs
Exotoxins / biosynthesis*
Female
Male
Pruritus / microbiology,  veterinary
Pyoderma / complications,  microbiology,  veterinary*
Recurrence
Staphylococcal Skin Infections / complications,  microbiology,  veterinary*
Staphylococcus / metabolism*
Chemical
Reg. No./Substance:
0/Exotoxins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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