| Comparison of potential risk factors for medication errors with and without patient harm. | |
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MedLine Citation:
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PMID: 20681001 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare determinants for medication errors leading to patient harm with determinants for medication errors without patient harm. METHODS: A two-way case-control design was used to identify determinants for medication errors without harm (substudy 1) and determinants for medication errors causing harm (substudy 2). Data of patients admitted to five internal medicine wards of two Dutch hospitals during 5 months were collected prospectively by chart review. Medication errors were detected and classified by two pharmacists. Consensus between five pharmacists was reached on the causal relationship between medication errors and patient harm. Data analysis was performed by multivariate logistic regression. RESULTS: We included 7286 medication orders, of which 3315 without errors (controls), and 5622 medication errors without harm (cases substudy 1) and 102 medication errors causing harm (cases substudy 2) were identified. Hospital, ward and the therapeutic class anti-infectives were associated with both medication errors without harm (hospital odds ratio (OR) 1.40; 95% confidence interval (CI) 1.21-1.63), TweeSteden hospital (TSh) geriatrics OR 2.03; 95% CI 1.73-2.38, TSh general internal medicine OR 1.44; 95% CI 1.23-1.69 and anti-infectives OR 1.28; 95% CI 1.06-1.56) and medication errors with harm (hospital OR 4.91; 95% CI 3.02-7.79, TSh geriatrics OR 5.76; 95% CI 2.52-13.15, TSh general internal medicine OR 6.51; 95% CI 2.82-15.02 and anti-infectives OR 4.20; 95% CI 2.24-7.90). CONCLUSIONS: This study shows that organisational determinants (hospital, ward) are comparable for medication errors with and without harm. For conclusions on patient- and medication-related determinants studies with larger sample sizes are needed. |
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Authors:
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Rianne J Zaal; Jasperien E van Doormaal; Albert W Lenderink; Peter G M Mol; Jos G W Kosterink; Toine C G Egberts; Flora M Haaijer-Ruskamp; Patricia M L A van den Bemt |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacoepidemiology and drug safety Volume: 19 ISSN: 1099-1557 ISO Abbreviation: Pharmacoepidemiol Drug Saf Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208369 Medline TA: Pharmacoepidemiol Drug Saf Country: England |
Other Details:
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Languages: eng Pagination: 825-33 Citation Subset: IM |
Copyright Information:
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2010 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Clinical Pharmacy, TweeSteden hospital, Tilburg, The Netherlands. rzaal@tsz.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Case-Control Studies Confidence Intervals Female Health Services for the Aged Hospitals Humans Internal Medicine Logistic Models Male Medication Errors* Middle Aged Odds Ratio Pharmaceutical Preparations / adverse effects* Pharmacists Pharmacy Service, Hospital Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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