Document Detail

Comparison of the potency of lidocaine and chloroprocaine in sciatic nerve block in Sprague-Dawley rats.
MedLine Citation:
PMID:  19420984     Owner:  NLM     Status:  MEDLINE    
AIM: This study investigates the relative potencies and ED(50) of the local anesthetics lidocaine and chloroprocaine in a sciatic block in Sprague-Dawley rats. METHODS: The study involved 80 rats (chloroprocaine n = 40, lidocaine n = 40). Each rat was injected close to the sciatic nerve with 0.1 ml of the concentration of local anesthetic being tested. Using the up-and-down allocation technique, the next concentration was determined by the response of the previous subject to a higher or lower concentration. A successful block was assessed by pinching the fifth metatarsal. Absent vocalization and a very weak withdrawal response were defined as the onset of block. RESULTS: Using the up-and-down methodology, the estimates of ED(50) for chloroprocaine was 0.1 ml of 1.2% (with 95% CI of 1.1-1.6), and that for lidocaine was 0.1 ml of 0.65% (with 95% CI of 0.65-0.88), giving a lidocaine/chloroprocaine potency ratio of 1.85 (with 95% CI of 1.66-2.61). DISCUSSION: Using the results of this study, the effects of the two drugs can be compared using the commercially available concentrations of chloroprocaine and lidocaine in a peripheral nerve block.
Elliot Yung; Joel M Yarmush; Jonathan Weinberg; Joseph J SchianodiCola; Sidhartha D Ray
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-07
Journal Detail:
Title:  Pharmacology     Volume:  83     ISSN:  1423-0313     ISO Abbreviation:  Pharmacology     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-09     Completed Date:  2009-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  356-9     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Department of Anesthesiology, New York Methodist Hospital, Brooklyn, NY 11215, USA.
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MeSH Terms
Anesthetics, Local / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Lidocaine / administration & dosage,  pharmacology*
Nerve Block*
Procaine / administration & dosage,  analogs & derivatives*,  pharmacology
Random Allocation
Rats, Sprague-Dawley
Sciatic Nerve / drug effects*
Reg. No./Substance:
0/Anesthetics, Local; 133-16-4/chloroprocaine; 137-58-6/Lidocaine; 59-46-1/Procaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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