| Comparison of positron emission tomography/computed tomography imaging and ultrasound in staging and surveillance of head and neck and thyroid cancer. | |
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MedLine Citation:
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PMID: 19688854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES/HYPOTHESIS: Positron emission tomography (PET) combined with cross-sectional computed tomography (CT) is increasingly used for staging and surveillance of cancers in the head and neck region. Ultrasonography (US) is an alternative imaging technique that provides diagnostic information while enabling simultaneous image-guided biopsies. A comparison of these diagnostic modalities in cancer detection is warranted. METHODS: All patients with malignant neoplasms in the head and neck region who were evaluated by both PET/CT and US were reviewed. Diagnostic accuracy rates of PET/CT and US were determined according to whether cytologically or histologically confirmed cancer was present in US-guided fine-needle biopsy or surgical specimens. RESULTS: From October 2004 to December 2007, 42 patients with an ultimately confirmed tissue diagnosis of a head and neck malignancy underwent both neck US and PET/CT. The sensitivity and specificity of US in predicting malignancy in the head and neck was 96.8% and 93.3%, respectively, in those 42 individuals. The positive predictive value (PPV) was 96% and the negative predictive value (NPV) was 93%. In comparison, PET/CT in this group demonstrated a sensitivity of 90.3%, specificity 20%, PPV 70%, and NPV 50%. CONCLUSIONS: PET/CT and US, especially when combined with US-guided fine-needle biopsy, are complementary tools in the detection of cancers of the head and neck. The highly sensitive and specific nature of US, combined with its low cost, low morbidity, availability as an in-office examination, and ability to guide biopsies, warrant consideration of its routine use in the management of head and neck and thyroid cancer patients. |
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Authors:
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Harry S Hwang; Daniel A Perez; Lisa A Orloff |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Laryngoscope Volume: 119 ISSN: 1531-4995 ISO Abbreviation: Laryngoscope Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-28 Completed Date: 2009-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: United States |
Other Details:
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Languages: eng Pagination: 1958-65 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology-Head and Neck Surgery, University of California-San Francisco, 2233 Post Street, San Francisco, CA 94115, U.S.A. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy, Fine-Needle Carcinoma, Squamous Cell / diagnosis*, radiography, radionuclide imaging, ultrasonography Diagnostic Imaging* Female Head and Neck Neoplasms / diagnosis*, radiography, radionuclide imaging, ultrasonography Humans Male Positron-Emission Tomography* Retrospective Studies Sensitivity and Specificity Thyroid Neoplasms / diagnosis*, radiography, radionuclide imaging, ultrasonography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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