| Comparison of positron emission tomography, computed tomography, and endoscopic ultrasound in the initial staging of patients with esophageal cancer. | |
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MedLine Citation:
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PMID: 16270235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Improvement in esophageal cancer staging is needed. Positron emission tomography (PET), computed tomography (CT), and endoscopic ultrasound (EUS) in the staging of esophageal carcinoma were compared. METHODS: PET, CT, and EUS were performed and interpreted prospectively in 75 patients with newly diagnosed esophageal cancer. Either tissue confirmation or fine needle aspiration (FNA) was used as the gold standard of disease. Sensitivity and specificity for tumor, nodal, and metastatic (TNM) disease for each test were determined. TNM categorizations from each test were used to assign patients to subgroups corresponding to the three treatment plans that patients could theoretically receive, and these were then compared. RESULTS: Local tumor staging (T) was done correctly by CT and PET in 42% and by EUS in 71% of patients (P value > 0.14). The sensitivity and specificity for nodal involvement (N) by modality were 84% and 67% for CT, 86% and 67% for EUS, and 82% and 60% for PET (P value > 0.38). The sensitivity and specificity for distant metastasis were 81% and 82% for CT, 73% and 86% for EUS, and 81% and 91% for PET (P value > 0.25). Treatment assignment was done correctly by CT in 65%, by EUS in 75%, and by PET in 70% of patients (P value > 0.34). CONCLUSIONS: EUS had superior T staging ability over PET and CT in our study group. The tests showed similar performance in nodal staging and there was a trend toward improved distant disease staging with CT or PET over EUS. Assignment to treatment groups in relation to TNM staging tended to be better by EUS. Each test contributed unique patient staging information on an individual basis. |
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Authors:
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Val J Lowe; Fargol Booya; J G Fletcher; Mark Nathan; Eric Jensen; Brian Mullan; Eric Rohren; Maurits J Wiersema; Enrique Vazquez-Sequeiros; Joseph A Murray; Mark S Allen; Michael J Levy; Jonathan E Clain |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Volume: 7 ISSN: 1536-1632 ISO Abbreviation: Mol Imaging Biol Publication Date: 2005 Nov-Dec |
Date Detail:
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Created Date: 2006-02-23 Completed Date: 2006-03-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101125610 Medline TA: Mol Imaging Biol Country: United States |
Other Details:
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Languages: eng Pagination: 422-30 Citation Subset: IM |
Affiliation:
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Department of Radiology, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA. vlowe@mayo.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Endosonography Esophageal Neoplasms / pathology, radionuclide imaging*, ultrasonography* Humans Lymph Nodes / radionuclide imaging, ultrasonography Neoplasm Metastasis / pathology, radionuclide imaging, ultrasonography Neoplasm Staging Sensitivity and Specificity Tomography, X-Ray Computed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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