| Comparison of portal vein velocity and the hepatic venous pressure gradient in assessing the acute portal hemodynamic response to propranolol in patients with cirrhosis. | |
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MedLine Citation:
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PMID: 11051366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this prospective study was to compare noninvasive Doppler sonography and invasive measurement of the hepatic venous pressure gradient (HVPG) to determine the acute portal hemodynamic response to propranolol in patients with liver cirrhosis. METHODS: In a blinded study design, portal vein velocity (PVV) and HVPG were simultaneously assessed in 11 cirrhotic patients for 4 h after oral ingestion of 40 mg propranolol. RESULTS: Both HVPG (17.2% +/- 4.3%, p < 0.0001) and PVV (15.6% +/- 2.1%, p < 0.0002) showed a highly significant reduction during the study period versus baseline. Based on HVPG measurements, four patients (36%) were classified as nonresponders. These patients had a significantly lower PVV reduction compared to the responders (responders: 18.8% +/- 2.0% vs nonresponders: 10.0% +/- 2.1%, p < 0.05). Nonresponders were identified by Doppler sonography with a sensitivity of 1.0, specificity of 0.86, and positive predictive value of 0.9 when a threshold of 20% PVV reduction 120 min after drug intake was applied. CONCLUSIONS: Doppler sonography is a useful tool for assessment of the acute portal hemodynamic effect of propranolol. To distinguish portal hemodynamic nonresponders from responders to propranolol, PVV measurements should be carried out 2 h after drug administration, and PVV reduction should be not <20% in propranolol responders. |
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Authors:
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M Schepke; P Raab; A Hoppe; P Schiedermaier; K A Brensing; T Sauerbruch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 95 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-11-08 Completed Date: 2000-11-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2905-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine I, University of Bonn, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Blood Flow Velocity / drug effects, physiology Female Hemodynamics / drug effects*, physiology Hepatic Veins / drug effects*, physiopathology, ultrasonography Humans Liver Cirrhosis / drug therapy*, physiopathology, ultrasonography Male Middle Aged Portal Pressure / drug effects*, physiology Portal System / drug effects*, physiopathology, ultrasonography Portal Vein / drug effects*, physiopathology, ultrasonography Propranolol / administration & dosage*, adverse effects Sensitivity and Specificity Treatment Outcome Ultrasonography, Doppler / drug effects |
| Chemical | |
Reg. No./Substance:
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525-66-6/Propranolol |
| Comments/Corrections | |
Comment In:
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Am J Gastroenterol. 2001 Jun;96(6):1947
[PMID:
11419865
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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