Document Detail


Comparison of population activity in the dorsal premotor cortex and putamen during the learning of arbitrary visuomotor mappings.
MedLine Citation:
PMID:  16284756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A previous study found that as monkeys learned novel mappings between visual cues and responses, neuronal activity patterns evolved at approximately the same time in both the dorsal premotor cortex (PMd) and the putamen. Here we report that, in both regions, the population activity for novel mappings came to resemble that for familiar ones as learning progressed. Both regions showed activity differences on trials with correct responses versus those with incorrect ones. In addition to these common features, we observed two noteworthy differences between PMd and putamen activity during learning. After a response choice had been made, but prior to feedback about the correctness of that choice (reward or nonreward), the putamen showed a sustained activity increase in activity, whereas PMd did not. Also in the putamen, this prereward activity was highly selective for the specific visuomotor mapping that had just been performed, and this selectivity was maintained until the time of the reward. After performance reached an asymptote, the degree of this selectivity decreased markedly to the level typical for familiar visuomotor mappings. These findings support the hypothesis that neurons in the striatum play a pivotal role in associative learning.
Authors:
Ethan R Buch; Peter J Brasted; Steven P Wise
Related Documents :
18671286 - Successful thalamic deep brain stimulation for orthostatic tremor.
11948756 - Mechanisms of deep brain stimulation.
11080546 - Interactions between rewarding lateral hypothalamic and aversive nucleus reticularis gi...
18842956 - Encoding by response duration in the basal ganglia.
21150916 - Slow integration leads to persistent action potential firing in distal axons of coupled...
15145756 - Esophagocardiac convergence onto thoracic spinal neurons: comparison of cervical and th...
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-11-12
Journal Detail:
Title:  Experimental brain research     Volume:  169     ISSN:  0014-4819     ISO Abbreviation:  Exp Brain Res     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-21     Completed Date:  2006-07-06     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  69-84     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Animals
Behavior, Animal
Brain Mapping*
Functional Laterality / physiology
Learning / physiology*
Macaca mulatta
Male
Motor Cortex / cytology*,  physiology
Neurons / physiology*
Photic Stimulation / methods
Psychomotor Performance
Putamen / cytology*,  physiology
Time Factors
Visual Perception / physiology*
Grant Support
ID/Acronym/Agency:
Z01 MH001092-27/MH/NIMH NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Short-latency afferent inhibition during selective finger movement.
Next Document:  The automatic extraction and use of information from cues and go signals in an anti-saccade task.